Department of Stroke Rehabilitation, Loewenstein Rehabilitation Hospital, Raanana and Sackler School of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel.
Restor Neurol Neurosci. 1995 Jan 1;9(2):77-83. doi: 10.3233/RNN-1995-9202.
Experimental animals with large posterior-cortical lesions develop disturbances of visual perception and visually-guided behavior in the contralateral space, resembling the syndrome of unilateral spatial neglect (USN) in humans. The visuo-motor performance in the ignored space is recovered some time following additional lesion inflicted to the contralesional superior colliculus or section of the intercollicular pathways. Based on the model that explains this recovery by disinhibition of the ipsilesional superior colliculus (the 'Sprague effect') Posner and Rafal [37] proposed that ipsilesional monocular occlusion could possibly reduce the 'tone' of contralesional collicular neurons thereby removing an important contributor of hemineglect. A group of twenty-six right-hemisphere-damaged patients with USN was given a cancellation task under binocular and monocular (left and right) viewing conditions. Thirteen patients showed amelioration of left hemineglect in conditions of left-monocular viewing, as compared to the baseline binocular state. Although this result superficially resembles the Sprague effect, two patients benefited from right-monocular viewing whereas eleven patients showed no significant change in either right or left viewing conditions. The possible role of structures mediating interocular differences in target detection in cases of right hemisphere damage is discussed. It is suggested that even if the Sprague effect contributes to the salubrious influence of monocular viewing it is hardly the single factor involved.
实验动物的大皮质后病变发展的干扰，视觉感知和视觉引导行为的对侧空间，类似于单侧空间忽略（USN）的人类。该 visuo 电机性能在忽略空间被恢复一段时间后额外的伤害造成的对侧上丘或部门的脑桥通路。基于模型解释了这种恢复的抑制作用同侧上丘（“斯普拉格效应”），波斯纳和拉法尔[37]提出同侧单眼遮盖可能会降低“色调”对侧丘神经元从而去除hemineglect 的一个重要贡献者。一组 26 例右半球损伤的单侧忽略患者在双眼和单眼（左、右）观察条件下进行了取消任务。13 例患者在左眼单眼观察条件下改善了左侧忽视，与基线双眼状态相比。虽然这一结果表面上类似于斯普拉格效应，但有 2 例患者受益于右眼单眼观察，而 11 例患者在右眼或左眼观察条件下均无明显变化。讨论了在右半球损伤的情况下，介导目标检测的眼间差异的结构的可能作用。有人认为，即使斯普拉格效应有助于单眼观察的有益影响，但它几乎不是唯一涉及的因素。
