Launo C, Palermo S, Germi M R, Lanfrit C, Frascà A, Simonetti F
Istituto di Anestesiologia e Rianimazione, Università degli Studi di Genova.
Minerva Anestesiol. 1991 Jul-Aug;57(7-8):427-31.
Clonidine was clinically evaluated to suppress postoperative shivering in 60 patients who had undergone anesthesia for general, thoracic and vascular surgery. The study was carried out in double blind conditions with comparison of two doses (75 and 150 micrograms) of clonidine, one dose of methylphenidate, and one dose of saline, as control group. The level of inhibition (Goldfarb scale), haemodynamics and temperature were studied. In conclusion, the methylphenidate is drug first choice for postoperative shivering, but clonidine inhibits postoperative shivering without haemodynamic and temperature variations (75 micrograms).
对60例接受全身、胸部和血管外科手术麻醉的患者进行了可乐定抑制术后寒战的临床评估。该研究在双盲条件下进行，比较了两剂（75微克和150微克）可乐定、一剂哌甲酯和一剂生理盐水作为对照组。研究了抑制水平（戈德法布量表）、血流动力学和体温。总之，哌甲酯是术后寒战的首选药物，但可乐定在不影响血流动力学和体温的情况下抑制术后寒战（75微克）。
