Jang Sung Ho, Ahn Sang Ho, Byun Woo Mok, Kim Chung Sun, Lee Mi Young, Kwon Yong Hyun
Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Republic of Korea.
Neurosci Lett. 2009 Aug 28;460(2):117-20. doi: 10.1016/j.neulet.2009.05.037. Epub 2009 May 18.
We attempted to evaluate whether cortical activation resulting from hand movements is changed by transcranial direct current stimulation (tDCS) applied on the primary motor cortex for the hand in the human brain, using functional MRI (fMRI).
Fourteen normal subjects were recruited; subjects were randomly assigned to either the tDCS group (n=7) or the sham group (n=7). fMRI was performed with hand grasp-release movements at 1Hz before and after 20 min of intervention (the tDCS group: anodal tDCS, the sham group: sham stimulation).
The activation of the tDCS underlying primary sensorimotor cortex (SM1) was significantly increased in the tDCS group (p<0.05). By contrast, the SM1 was significantly decreased in the sham group in terms of the voxel count and intensity (p<0.05). No subjects complained of any adverse symptoms or signs.
We demonstrated that anodal tDCS increased the cortical excitability of the underlying motor cortex in the human brain. It seems that tDCS is an effective modality to modulate brain function.
我们试图利用功能磁共振成像（fMRI）评估在人脑中，经颅直流电刺激（tDCS）作用于手部初级运动皮层时，手部运动引起的皮层激活是否会发生变化。
招募了14名正常受试者；受试者被随机分为tDCS组（n = 7）或假刺激组（n = 7）。在干预20分钟前后（tDCS组：阳极tDCS，假刺激组：假刺激），以1Hz的频率进行手部抓握 - 松开运动的fMRI检查。
tDCS组中，初级感觉运动皮层（SM1）下方的tDCS激活显著增加（p < 0.05）。相比之下，假刺激组的SM1在体素数量和强度方面显著降低（p < 0.05）。没有受试者抱怨任何不良症状或体征。
我们证明阳极tDCS增加了人脑中基础运动皮层的皮层兴奋性。似乎tDCS是调节脑功能的一种有效方式。
