Kwon Yong Hyun, Ko Myoung-Hwan, Ahn Sang Ho, Kim Yun-Hee, Song Jun Chan, Lee Chu-Hee, Chang Min Cheol, Jang Sung Ho
Department of Physical Therapy, Yeungnam College of Science and Technology, Republic of Korea.
Neurosci Lett. 2008 Apr 11;435(1):56-9. doi: 10.1016/j.neulet.2008.02.012. Epub 2008 Feb 12.
Transcranial direct current stimulation (tDCS) can modulate motor cortex excitability in the human brain. We attempted to demonstrate the cortical stimulation effect of tDCS on the primary motor cortex (M1) using functional MRI (fMRI). An fMRI study was performed for 11 right-handed healthy subjects at 1.5 T. Anodal tDCS was applied to the scalp over the central knob of the M1 in the left hemisphere. A constant current with an intensity of 1.0 mA was applied. The total fMRI paradigm consisted of three sessions with a 5-min resting period between each session. Each session consisted of five successive phases (resting-tDCS-tDCS-tDCS-tDCS), and each of the phases was performed for 21s. Our findings revealed that no cortical activation was detected in any of the stimulation phases except the fourth tDCS phase. In the result of group analysis for the fourth tDCS phase, the average map indicated that the central knob of the left primary motor cortex was activated. In addition, there were activations on the left supplementary motor cortex and the right posterior parietal cortex. We demonstrated that tDCS has a direct stimulation effect on the underlying cortex. It seems that tDCS is a useful modality for stimulating a target cortical region.
经颅直流电刺激（tDCS）可调节人脑运动皮层的兴奋性。我们试图使用功能磁共振成像（fMRI）来证明tDCS对初级运动皮层（M1）的皮层刺激效果。对11名右利手健康受试者进行了1.5T的fMRI研究。阳极tDCS施加于左半球M1中央隆起上方的头皮。施加强度为1.0mA的恒定电流。整个fMRI范式包括三个阶段，每个阶段之间有5分钟的休息期。每个阶段由五个连续的时期（静息-tDCS-tDCS-tDCS-tDCS）组成，每个时期持续21秒。我们的研究结果显示，除了第四个tDCS时期外，在任何刺激时期均未检测到皮层激活。在对第四个tDCS时期的组分析结果中，平均图谱表明左初级运动皮层的中央隆起被激活。此外，左辅助运动皮层和右后顶叶皮层也有激活。我们证明了tDCS对其下方的皮层有直接刺激作用。似乎tDCS是刺激目标皮层区域的一种有用方式。
