达托霉素能迅速穿透表皮葡萄球菌生物被膜。

Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm.

作者信息

Stewart Philip S, Davison William M, Steenbergen Judith N

机构信息

Center for Biofilm Engineering, Department of Chemical and Biological Engineering, Montana State University, Bozeman, MT 59717-3980, USA.

出版信息

Antimicrob Agents Chemother. 2009 Aug;53(8):3505-7. doi: 10.1128/AAC.01728-08. Epub 2009 May 18.

DOI:10.1128/AAC.01728-08

PMID:19451285

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2715639/

Abstract

Fluorescently tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm.

摘要

荧光标记的达托霉素在数分钟内就能进入表皮葡萄球菌生物膜细胞簇内部。达托霉素在生物膜中的扩散系数是其在纯水中扩散系数的28%。达托霉素对生物膜中嵌入的葡萄球菌的活性不太可能受到抗生素渗透进入生物膜的限制。