School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
J Nat Med. 2009 Oct;63(4):380-5. doi: 10.1007/s11418-009-0340-x. Epub 2009 May 19.
Valerena-4,7(11)-diene and beta-maaliene were isolated from spikenard for the first time, and the effects of inhaling these compounds were investigated. Both compounds reduced the locomotor activity of mice dose-dependently, even at a low dose. Valerena-4,7(11)-diene had a particularly profound effect, with the strongest sedative activity observed at a dose of 0.06%. Caffeine-treated mice that showed an area under the curve (AUC) for locomotor activity that was double that of controls were calmed to normal levels by administration of valerena-4,7(11)-diene. The continuous sleep time of pentobarbital-treated mice was prolonged by about 2.7 times with valerena-4,7(11)-diene, an effect similar to that of chlorpromazine administered orally.
螺旋千金藤烯二酮和β-马缨丹烯首次从缬草中分离出来，并对其吸入效果进行了研究。这两种化合物都能使小鼠的运动活性呈剂量依赖性降低，即使在低剂量下也是如此。螺旋千金藤烯二酮的作用尤其显著，在 0.06%的剂量下观察到最强的镇静活性。给予缬草烯二酮后，咖啡因处理的小鼠的运动活性曲线下面积（AUC）是对照组的两倍，其活动被镇静至正常水平。给予缬草烯二酮可使戊巴比妥处理的小鼠的连续睡眠时间延长约 2.7 倍，其效果类似于口服氯丙嗪。
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