威尔士耐环丙沙星弯曲杆菌感染的风险因素。

Risk factors for ciprofloxacin-resistant Campylobacter infection in Wales.

作者信息

Evans Meirion R, Northey Gemma, Sarvotham Tinnu S, Hopkins A Lynne, Rigby Christine J, Thomas Daniel Rh

机构信息

Department of Primary Care and Public Health, Cardiff University, Cardiff, UK.

出版信息

J Antimicrob Chemother. 2009 Aug;64(2):424-7. doi: 10.1093/jac/dkp179. Epub 2009 May 19.

DOI:10.1093/jac/dkp179

PMID:19454522

Abstract

OBJECTIVES

To identify risk factors for ciprofloxacin resistance in both travel-related and domestically acquired Campylobacter infection.

METHODS

Case-comparison study of patients with ciprofloxacin-resistant and ciprofloxacin-susceptible Campylobacter infection conducted in Wales during 2003 and 2004.

RESULTS

Foreign travel was the major risk factor for ciprofloxacin-resistant infection [adjusted odds ratio (adjOR) 24.0, 95% confidence interval (95% CI) 12.6-45.9]. Among travellers, case patients were five times more likely to drink still bottled water (adjOR 4.7, 95% CI 1.0-21.7), whilst among non-travellers, case patients were three times more likely to drink sparkling bottled water (adjOR 3.3, 95% CI 1.5-7.4). There was no increased risk associated with eating poultry or prior quinolone use.

CONCLUSIONS

Foreign travel remains the most important risk factor for ciprofloxacin-resistant Campylobacter infection. The possible association of both domestic- and travel-related ciprofloxacin-resistant Campylobacter infection with bottled water needs to be further explored.

摘要

目的

确定旅行相关和国内获得性弯曲杆菌感染中对环丙沙星耐药的危险因素。

方法

2003年至2004年在威尔士对环丙沙星耐药和环丙沙星敏感的弯曲杆菌感染患者进行病例对照研究。

结果

出国旅行是环丙沙星耐药感染的主要危险因素[调整优势比（adjOR）24.0，95%置信区间（95%CI）12.6 - 45.9]。在旅行者中，病例患者饮用静止瓶装水的可能性是对照组的五倍（adjOR 4.7，95%CI 1.0 - 21.7），而在非旅行者中，病例患者饮用气泡瓶装水的可能性是对照组的三倍（adjOR 3.3，95%CI 1.5 - 7.4）。食用家禽或先前使用喹诺酮类药物与感染风险增加无关。