细胞色素c缺失导致的线粒体功能障碍会损害辐射诱导的旁观者效应。
Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect.
作者信息
Yang G, Wu L, Chen S, Zhu L, Huang P, Tong L, Zhao Y, Zhao G, Wang J, Mei T, Xu A, Wang Y
机构信息
State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing 100871, People's Republic of China.
出版信息
Br J Cancer. 2009 Jun 16;100(12):1912-6. doi: 10.1038/sj.bjc.6605087. Epub 2009 May 19.
Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome c is essential for the bystander effect.
细胞色素c是一种关键蛋白质，作为线粒体呼吸的组成部分和凋亡启动因子存在于线粒体中。我们利用缺乏细胞色素c的鼠细胞表明，缺乏细胞色素c的细胞对辐射诱导的旁观者信号所产生的活性氧/一氧化氮和微核诱导作用减弱，这表明细胞色素c对旁观者效应至关重要。
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