Grobman William A, Auger Melissa, Shulman Lee P, Elias Sherman
Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Prenat Diagn. 2009 Aug;29(8):800-3. doi: 10.1002/pd.2296.
To determine whether an association exists between prenatal diagnostic procedures and preeclampsia.
All women who underwent invasive prenatal diagnosis and were not at high risk for preeclampsia were identified during a 15-month period and matched by age with women who had not had invasive prenatal diagnosis. The association between prenatal diagnosis [amniocentesis and chorionic villus sampling (CVS)] and the development of preeclampsia was assessed in univariable and multivariable analyses.
Six-hundred and fifty-three women who underwent prenatal diagnosis (501 by amniocentesis and 152 by CVS) were matched by age with 653 women who did not undergo the test. In multivariable analysis, the factors that remained significantly associated with preeclampsia were (1) maternal age less than 25 years (OR 7.4, 95% CI 23.3-23.6); (2) nulliparity (OR 2.7, 95% CI 1.1-6.9); and (3) having had a CVS as a nulliparous woman (OR 4.2, 95% CI 1.4-12.6).
These data suggest that CVS is associated with the subsequent development of preeclampsia in nulliparous women; this relationship should be confirmed in further studies.
确定产前诊断程序与子痫前期之间是否存在关联。
在15个月期间，识别出所有接受侵入性产前诊断且无子痫前期高风险的女性，并按年龄与未接受侵入性产前诊断的女性进行匹配。在单变量和多变量分析中评估产前诊断[羊膜穿刺术和绒毛取样（CVS）]与子痫前期发生之间的关联。
653名接受产前诊断的女性（501例行羊膜穿刺术，152例行CVS）按年龄与653名未接受该检查的女性进行匹配。在多变量分析中，与子痫前期仍显著相关的因素为：（1）母亲年龄小于25岁（比值比7.4，95%置信区间23.3 - 23.6）；（2）未生育（比值比2.7，95%置信区间1.1 - 6.9）；（3）未生育女性行CVS（比值比4.2，95%置信区间1.4 - 12.6）。
这些数据表明，未生育女性行CVS与随后发生子痫前期有关；这种关系应在进一步研究中得到证实。
