Coseri Sergiu
Petru Poni Institute of Macromolecular Chemistry, 41A, Gr. Ghica Voda Alley, 700487, Iasi, Romania.
Mini Rev Med Chem. 2009 May;9(5):560-71. doi: 10.2174/138955709788167592.
Every year about 7 million people die from of various types of cancer, making this disease responsible for 12.5% of deaths worldwide. Consequently, there is an overwhelming demand to develop new, more potent and effective, anticancer drugs. Natural products represent the most valuable source with inexhaustible reserves, in which the researchers work could identify novel active agents that may serve as the leads and scaffolds for transformation into desperately needed efficacious drugs. This paper is devoted to reviewing some of the most outstanding achievements in the application of natural products as models and precursors for anticancer agents published in the post 2000 literature. Particular emphasis is placed on the chemical modification of active principles isolated from natural products, in hope of obtaining the desirable derivatives for the treatment of different types of cancer, including pancreatic, gastric, breast, colon cancers and leukemia.
每年约有700万人死于各类癌症，这一疾病导致全球12.5%的人口死亡。因此，开发新型、更有效且高效的抗癌药物的需求极为迫切。天然产物是储量无穷的最宝贵资源，研究人员可从中找到新型活性剂，这些活性剂可用作先导物和支架，转化为急需的有效药物。本文旨在综述2000年以后发表的将天然产物用作抗癌剂模型和前体的一些最杰出成果。特别强调对从天然产物中分离出的活性成分进行化学修饰，以期获得用于治疗不同类型癌症（包括胰腺癌、胃癌、乳腺癌、结肠癌和白血病）的理想衍生物。
