具有抗肿瘤活性的内生真菌天然产物。

Natural products with antitumor activity from endophytic fungi.

机构信息

Institute of Biotechnology, Zhejiang University, Hangzhou 310058, China.

出版信息

Mini Rev Med Chem. 2011 Oct;11(12):1056-74. doi: 10.2174/138955711797247716.

Abstract

Endophytic fungi are a seemingly inexhaustible source of novel bioactive natural products. Currently, more than 140 fungal metabolites have shown confirmed activity in tumor cell line bioassays. We present the chemical structures of these antitumor metabolites, their corresponding fungal endophytes and host plants, and the activities they exhibited, and briefly discuss some of their action mechanisms. This review emphasizes the role of endophytic fungi as an important source of leads for drug discoveries.

摘要

内生真菌是新型生物活性天然产物的似乎无穷无尽的来源。目前，已有超过 140 种真菌代谢产物在肿瘤细胞系生物测定中表现出明确的活性。我们介绍了这些抗肿瘤代谢产物的化学结构、它们相应的真菌内生菌和宿主植物，以及它们表现出的活性，并简要讨论了它们的一些作用机制。本综述强调了内生真菌作为药物发现重要先导化合物来源的作用。