Janssen Tom, Meelkop Ellen, Nachman Ronald J, Schoofs Liliane
Functional Genomics and Proteomics Unit, Department of Biology, Katholieke Universiteit Leuven, Leuven, Belgium.
Ann N Y Acad Sci. 2009 Apr;1163:428-32. doi: 10.1111/j.1749-6632.2008.03649.x.
Members of the cholecystokinin (CCK)/gastrin family of peptides, including the arthropod sulfakinins and their cognate receptors, play an important role in the regulation of feeding behavior and energy homeostasis. By using the potential Caenorhabditis elegans CCK receptors as bait, we have isolated and identified two CCK-like neuropeptides as the endogenous ligands of these nematode receptors. Both receptors and ligands share a high degree of sequence similarity with their vertebrate and arthropod counterparts and also display similar biological activities with respect to digestive enzyme secretion and fat storage. Our data indicate that the CCK/gastrin signaling system was already well established prior to the divergence of protostomes and deuterostomes.
包括节肢动物促胃液素释放肽及其同源受体在内的缩胆囊素（CCK）/胃泌素肽家族成员在进食行为和能量稳态调节中发挥重要作用。通过使用潜在的秀丽隐杆线虫CCK受体作为诱饵，我们分离并鉴定了两种CCK样神经肽作为这些线虫受体的内源性配体。受体和配体与它们的脊椎动物和节肢动物对应物都具有高度的序列相似性，并且在消化酶分泌和脂肪储存方面也表现出相似的生物学活性。我们的数据表明，CCK/胃泌素信号系统在原口动物和后口动物分化之前就已经很好地建立起来了。
