Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, E/CLS639, Boston, MA 02215, USA.
Curr Pain Headache Rep. 2009 Jun;13(3):237-40. doi: 10.1007/s11916-009-0040-y.
Migraine pain has been attributed to an episode of local sterile meningeal inflammation and the subsequent activation of trigeminal primary afferent nociceptive neurons that supply the intracranial meninges and their related large blood vessels. However, the origin of this inflammatory insult and the endogenous factors that contribute to the activation of meningeal nociceptors remain largely speculative. A particular class of inflammatory cells residing within the intracranial milieu, known as meningeal mast cells, was suggested to play a role in migraine pathophysiology more than five decades ago, but until recently the exact nature of their involvement remained largely unexplored. This review examines the evidence linking meningeal mast cells to migraine and highlights current experimental data implicating these immune cells as potent modulators of meningeal nociceptors' activity and the genesis of migraine pain.
偏头痛疼痛被归因于局部无菌性脑膜炎症和随后三叉神经初级传入伤害感受器神经元的激活，这些神经元供应颅内脑膜及其相关的大血管。然而，这种炎症损伤的起源以及导致脑膜伤害感受器激活的内源性因素在很大程度上仍在推测之中。五十多年前，人们提出，存在于颅内环境中的一类特殊的炎性细胞，即脑膜肥大细胞，可能在偏头痛病理生理学中发挥作用，但直到最近，其确切的参与方式仍在很大程度上尚未得到探索。这篇综述审查了将脑膜肥大细胞与偏头痛联系起来的证据，并强调了目前的实验数据表明这些免疫细胞是脑膜伤害感受器活性和偏头痛疼痛产生的有力调节因子。
