Djasim U M, Mathot B J, Wolvius E B, van Neck J W, van der Wal K G H
Department of Oral and Maxillofacial Surgery, The Netherlands.
J Craniomaxillofac Surg. 2009 Oct;37(7):398-404. doi: 10.1016/j.jcms.2009.03.006. Epub 2009 May 19.
Experimental research on optimising the distraction protocol has been performed extensively in the past. However, relatively little research has been done on the rhythm of distraction. Findings in the orthopaedic literature showed that the outcome of distraction osteogenesis (DO) is positively influenced by increasing the rhythm of distraction. The aim of this study is to quantitatively compare continuous with discontinuous rhythms of distraction in rabbits.
Tissue blocks of regenerated bone were harvested from thirty-eight young adult female New-Zealand White rabbits. After a latency period of three days, rabbits were subjected for eleven days to either single daily activation of the distractor at a rate of 0.9 mm/d, or triple daily activation at a rate of 0.9 mm/d, or continuous activation at a rate of 0.9 mm/d. After three weeks of consolidation, bone regenerates were analysed using histomorphometry.
The continuous DO group showed significantly (p<.01) more regenerate bone volume in the central part of the regenerate than the discontinuous DO groups. Higher osteoblastic activity was seen, as well as more blood vessels (p<.05). Bone volume and the number of blood vessels correlated significantly in the central part of the regenerate (p<.05). Also, the early mineral apposition rate (MAR) was higher than the late MAR (p<.05).
Continuous DO significantly accelerates bone formation when compared with discontinuous DO.
过去已经对优化牵引方案进行了广泛的实验研究。然而，关于牵引节奏的研究相对较少。骨科文献中的研究结果表明，增加牵引节奏对牵张成骨（DO）的结果有积极影响。本研究的目的是定量比较兔连续与不连续牵引节奏。
从38只成年雌性新西兰白兔获取再生骨组织块。经过3天的潜伏期后，将兔子分为三组，分别进行为期11天的实验：每天以0.9毫米/天的速率单次激活牵引器，或每天以0.9毫米/天的速率三次激活牵引器，或以0.9毫米/天的速率连续激活牵引器。在巩固3周后，使用组织形态计量学分析骨再生情况。
与不连续牵张成骨组相比，连续牵张成骨组在再生骨中央部分显示出显著更多的再生骨体积（p<.01）。观察到更高的成骨细胞活性以及更多的血管（p<.05）。再生骨中央部分的骨体积与血管数量显著相关（p<.05）。此外，早期矿物质沉积率（MAR）高于晚期MAR（p<.05）。
与不连续牵张成骨相比，连续牵张成骨显著加速骨形成。
