Kiliç Erdem, Ozeç Ilker, Yeler Hasan, Korkmaz Adnan, Ayas Bülent, Gümüş Cesur
Department of Oral and Maxillofacial Surgery, Dental School, Erciyes University, Kayseri, Turkey.
J Oral Maxillofac Surg. 2008 Nov;66(11):2233-8. doi: 10.1016/j.joms.2008.05.362.
The aim of this study was to evaluate the effects of local and systemic simvastatin application on distraction osteogenesis.
Eighteen New Zealand white rabbits underwent unilateral mandibular distraction osteogenesis. After 7 days of neutral fixation, 0.4 mm twice per day, distraction was performed for 10 days. Simvastatin was applied locally during the osteotomy phase with a gelatin sponge carrier and systemically during the distraction osteogenesis period by oral gavage. All animals were killed at the end of the consolidation period of 14 days. The distracted mandibles were harvested and evaluated by plain radiography, by peripheral quantitative computed tomography, and with histomorphometry.
Radiographic evaluation with peripheral quantitative computed tomography showed that the area of the regenerate increased by 9.6% in the local simvastatin group and by 19.3% in the systemic simvastatin group as compared with the control group. In both experimental groups the density of the regenerate increased by 6.7% as compared with the control group. Statistical evaluation of radiographic data showed that all of these changes were not significant. Histomorphometric evaluation determined that there was no statistical difference among groups with regard to the ratios of bone tissue volume to fibrous tissue volume and bone tissue volume to marrow tissue volume.
The results of this study suggest that simvastatin's effect on enhancing distraction regenerate is limited with the applied doses and methods.
本研究旨在评估局部和全身应用辛伐他汀对牵张成骨的影响。
18只新西兰白兔接受单侧下颌骨牵张成骨。在中立固定7天后，每天两次，每次0.4毫米，进行10天的牵张。在截骨期用明胶海绵载体局部应用辛伐他汀，在牵张成骨期通过口服灌胃全身应用辛伐他汀。所有动物在14天的巩固期结束时处死。取出牵张后的下颌骨，通过X线平片、外周定量计算机断层扫描和组织形态计量学进行评估。
外周定量计算机断层扫描的影像学评估显示，与对照组相比，局部应用辛伐他汀组的再生面积增加了9.6%，全身应用辛伐他汀组增加了19.3%。与对照组相比，两个实验组的再生密度均增加了6.7%。影像学数据的统计学评估显示，所有这些变化均无统计学意义。组织形态计量学评估确定，在骨组织体积与纤维组织体积之比以及骨组织体积与骨髓组织体积之比方面，各组之间无统计学差异。
本研究结果表明，在所应用的剂量和方法下，辛伐他汀对增强牵张再生的作用有限。
