Kaneko Hisatoshi, Ishiko Hiroaki, Ohguchi Takeshi, Tagawa Yoshitsugu, Aoki Koki, Suzutani Tatsuo, Ohno Shigeaki
Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima, Japan.
J Gen Virol. 2009 Sep;90(Pt 9):2260-5. doi: 10.1099/vir.0.010934-0. Epub 2009 May 20.
Human adenovirus type 8 (HAdV-8) and 37 (HAdV-37) cause epidemic keratoconjunctivitis (EKC) associated with community-acquired and nosocomial infections. The nucleotide sequences of the entire hexon and fiber genes of eight HAdV-8 and 26 HAdV-37 strains were analysed and the transition mutations in each gene were compared among strains. Compared with prototype strains, the hexon gene of HAdV-8 and -37 strains showed between two and seven and one and twelve variations at nine and 21 different positions, respectively. All of these, except one position in HAdV-37, were located in the conserved region 4 (C4). There were only three polymorphisms in the fiber gene of both HAdV-8 and HAdV-37, fewer than those in C4. The nucleotide sequence of HAdV-8 and -37 C4 might be readily modified during EKC epidemics.
人8型腺病毒（HAdV-8）和37型腺病毒（HAdV-37）可引起与社区获得性感染和医院感染相关的流行性角结膜炎（EKC）。分析了8株HAdV-8和26株HAdV-37菌株的整个六邻体和纤维基因的核苷酸序列，并比较了各菌株每个基因中的转换突变。与原型菌株相比，HAdV-8和-37菌株的六邻体基因分别在9个和21个不同位置显示出2至7个和1至12个变异。除HAdV-37中的一个位置外，所有这些变异都位于保守区域4（C4）。HAdV-8和HAdV-37的纤维基因中只有三个多态性，比C4中的少。在EKC流行期间，HAdV-8和-37 C4的核苷酸序列可能很容易发生改变。
