米诺环素作为一种潜在的治疗药物，用于治疗以蛋白质错误折叠为特征的神经退行性疾病。
Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding.
作者信息
Noble Wendy, Garwood Claire J, Hanger Diane P
机构信息
Department of Neuroscience, MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, London, UK.
出版信息
Prion. 2009 Apr-Jun;3(2):78-83. doi: 10.4161/pri.3.2.8820. Epub 2009 Apr 21.
Abstract
Many neurodegenerative disorders share common features including the accumulation of aggregated misfolded proteins, neuroinflammation and the induction of apoptosis. While the contributions of each of these individual elements to neuronal death remain unclear, a commonly used antibiotic, minocycline, has been shown to reduce the progression and severity of disease in several models of neurodegeneration by variously downregulating these molecular pathways. Here we discuss the evidence for the potential of minocycline as a broad-specificity therapeutic agent for those neurodegenerative diseases that are characterized by the presence of misfolded proteins.
摘要
许多神经退行性疾病具有共同特征，包括错误折叠蛋白的聚集、神经炎症以及细胞凋亡的诱导。虽然这些个体因素对神经元死亡的具体作用尚不清楚，但一种常用抗生素米诺环素已被证明，在多种神经退行性疾病模型中，通过不同程度地下调这些分子途径，可减缓疾病进展并减轻疾病严重程度。在此，我们讨论米诺环素作为一种具有广泛特异性的治疗药物，对那些以错误折叠蛋白存在为特征的神经退行性疾病的治疗潜力的相关证据。
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本文引用的文献
1
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Trends Mol Med. 2009 Mar;15(3):112-9. doi: 10.1016/j.molmed.2009.01.003. Epub 2009 Feb 24.
2
Protein misfolding and aggregation in Parkinson's disease.帕金森病中的蛋白质错误折叠和聚集。
Antioxid Redox Signal. 2009 Sep;11(9):2119-34. doi: 10.1089/ars.2009.2490.
3
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.细胞朊蛋白介导β-淀粉样寡聚体对突触可塑性的损害。
Nature. 2009 Feb 26;457(7233):1128-32. doi: 10.1038/nature07761.
4
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.在神经退行性变的细胞模型中，帕金森病相关蛋白富含亮氨酸重复序列激酶2通过死亡结构域相关蛋白Fas和半胱天冬酶-8转导死亡信号。
J Neurosci. 2009 Jan 28;29(4):1011-6. doi: 10.1523/JNEUROSCI.5175-08.2009.
5
Prion protein misfolding and disease.朊病毒蛋白错误折叠与疾病。
Curr Opin Struct Biol. 2009 Feb;19(1):14-22. doi: 10.1016/j.sbi.2008.12.007. Epub 2009 Jan 20.
6
Molecular basis of Parkinson's disease.帕金森病的分子基础
Neuroreport. 2009 Jan 28;20(2):150-6. doi: 10.1097/WNR.0b013e32831c50df.
7
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis.晚发性阿尔茨海默病中β-淀粉样蛋白与tau蛋白的关联：双途径假说
Neuron. 2008 Nov 26;60(4):534-42. doi: 10.1016/j.neuron.2008.11.007.
8
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J Neurovirol. 2008 Oct;14(5):376-88. doi: 10.1080/13550280802199898. Epub 2008 Nov 12.
9
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FASEB J. 2009 Mar;23(3):739-50. doi: 10.1096/fj.08-113795. Epub 2008 Nov 11.
10
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Neuroscience. 2008 Aug 26;155(3):725-37. doi: 10.1016/j.neuroscience.2008.06.036. Epub 2008 Jun 19.
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