Cankaya Seyda, Cankaya Baris, Kilic Ulkan, Kilic Ertugrul, Yulug Burak
Department of Neurology, Faculty of Medicine, Alaaddin Keykubat University, Alanya, Turkey.
Department of Anesthesiology and Reanimation, Marmara University Pendik Education and Research Hospital, Istanbul, Turkey.
Drugs Context. 2019 Mar 6;8:212553. doi: 10.7573/dic.212553. eCollection 2019.
Minocycline, a semisynthetic tetracycline-derived antibiotic, has been shown to exert anti-apoptotic, anti-inflammatory, and antioxidant effects. Furthermore, there is rapidly growing evidence suggesting that minocycline may have some neuroprotective activity in various experimental models such as cerebral ischemia, traumatic brain injury, amyotrophic lateral sclerosis, Parkinson's disease (PD), Huntington's disease, and multiple sclerosis. In this perspective review, we summarize the preclinical and clinical findings suggesting the neuroprotective role of minocycline in PD.
米诺环素是一种半合成的四环素类抗生素，已被证明具有抗凋亡、抗炎和抗氧化作用。此外，越来越多的证据表明，米诺环素在各种实验模型中可能具有一定的神经保护活性，如脑缺血、创伤性脑损伤、肌萎缩侧索硬化症、帕金森病（PD）、亨廷顿舞蹈症和多发性硬化症。在这篇观点综述中，我们总结了提示米诺环素在帕金森病中具有神经保护作用的临床前和临床研究结果。
