常规使用鼻持续气道正压通气进行湿化。

Routine use of humidification with nasal continuous positive airway pressure.

机构信息

Department of Respiratory and Sleep Medicine, Austin Hospital, Melbourne, Victoria, Australia.

出版信息

Intern Med J. 2010 Sep;40(9):650-6. doi: 10.1111/j.1445-5994.2009.01969.x.

DOI:10.1111/j.1445-5994.2009.01969.x

PMID:19460056

Abstract

BACKGROUND

Heated humidification can reduce nasal symptoms caused by continuous positive airway pressure (CPAP) treatment, but its routine use has not been studied over the medium term in a randomized controlled trial. The aim of this study is to determine if heated humidification would reduce nasal symptoms and improve adherence with CPAP treatment in all patients with sleep apnoea irrespective of whether they had nasal symptoms initially.

METHODS

A randomized, parallel group design. Patients were treated for 3 months with a Fisher & Paykel HC201 pump with built-in heated humidification, or with the heater disabled and without water. Adherence was measured with a timer built into the pumps. Nasal symptoms were measured with a 10-cm visual analogue scale.

RESULTS

There were 25 in the humidification group and 29 in the non-humidification group. After 12 weeks mean (standard deviation) adherence with CPAP was 4.7 (2.4) and 4.5 (2.2) hours per night respectively. Nasal symptoms that were reduced were nose blocked* 6 (12), 18 (26); sneezing* 4 (8), 15 (25); dry nose* 8 (12), 24 (33); stuffy nose* 7 (14), 22(31); dry mouth* 13 (18), 33(36); and runny nose* 6 (17), 14 (29). Parameters marked with an asterisk '*' had P < 0.05 with t-tests.

CONCLUSION

The routine use of heated humidification with CPAP in all patients with sleep apnoea reduced nasal symptoms, but did not improve adherence.

摘要

背景

加热湿化能减轻持续气道正压通气（CPAP）治疗引起的鼻部症状，但在随机对照试验中尚未对其在中期内的常规应用进行研究。本研究旨在确定加热湿化是否会降低所有睡眠呼吸暂停患者的鼻部症状，并提高 CPAP 治疗的依从性，无论他们最初是否有鼻部症状。

方法

这是一项随机、平行分组设计的研究。患者接受 3 个月的 Fisher & Paykel HC201 泵内置加热湿化治疗，或使用不带加热和水的泵。依从性通过内置在泵中的定时器进行测量。鼻部症状采用 10cm 视觉模拟量表进行测量。

结果

加热湿化组有 25 例，非加热湿化组有 29 例。12 周后，CPAP 的平均（标准差）依从性分别为 4.7（2.4）和 4.5（2.2）小时/夜。减轻的鼻部症状有鼻塞6（12）、18（26）；打喷嚏4（8）、15（25）；鼻干8（12）、24（33）；鼻塞7（14）、22（31）；口干13（18）、33（36）；流涕6（17）、14（29）。标有星号*的参数经 t 检验有统计学意义（P<0.05）。