Fisher Beth E, Davenport Todd E, Kulig Kornelia, Wu Allan D
Neuroplasticity and Imaging Laboratory, Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, Los Angeles, California, USA.
BMC Neurol. 2009 May 21;9:20. doi: 10.1186/1471-2377-9-20.
Many health care practitioners use a variety of hands-on treatments to improve symptoms and disablement in patients with musculoskeletal pathology.Research to date indirectly suggests a potentially broad effect of manual therapy on the neuromotor processing of functional behavior within the supraspinal central nervous system (CNS) in a manner that may be independent of modification at the level of local spinal circuits. However, the effect of treatment speed, as well as the specific mechanism and locus of CNS changes, remain unclear.
METHODS/DESIGN: We developed a placebo-controlled, randomized study to test the hypothesis that manual therapy procedures directed to the talocrural joint in individuals with post-acute ankle sprain induce a change in corticospinal excitability that is relevant to improve the performance of lower extremity functional behavior.
This study is designed to identify potential neuromotor changes associated with manual therapy procedures directed to the appendicular skeleton, compare the relative effect of treatment speed on potential neuromotor effects of manual therapy procedures, and determine the behavioral relevance of potential neuromotor effects of manual therapy procedures.
http://www.clinicaltrials.gov identifier NCT00847769.
许多医疗从业者采用多种手法治疗来改善肌肉骨骼疾病患者的症状和功能障碍。迄今为止的研究间接表明，手法治疗可能对脊髓上中枢神经系统（CNS）内功能行为的神经运动处理产生广泛影响，其方式可能独立于局部脊髓回路水平的改变。然而，治疗速度的影响以及CNS变化的具体机制和部位仍不清楚。
方法/设计：我们开展了一项安慰剂对照的随机研究，以检验以下假设：针对急性后踝关节扭伤个体的距小腿关节进行手法治疗程序可引起皮质脊髓兴奋性变化，这与改善下肢功能行为表现相关。
本研究旨在确定与针对附属骨骼的手法治疗程序相关的潜在神经运动变化，比较治疗速度对手法治疗程序潜在神经运动效应的相对影响，并确定手法治疗程序潜在神经运动效应的行为相关性。
http://www.clinicaltrials.gov 标识符NCT00847769。
