Sui Jianjun, Zhang Jianhua, Ching Chi Bun, Chen Wei Ning
School of Chemical and Biomedical Engineering, College of Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore.
Mol Biosyst. 2009 Jun;5(6):603-8. doi: 10.1039/b903858b. Epub 2009 Apr 28.
The chiralities of chiral drugs have been investigated extensively with the purpose of enlightening the role of chirality in drug action. Proteomics, though in its infancy, has recently emerged as the foremost technology in drug development research, possessing the advantage of providing more useful information about an organism than genomics, as it directly addresses the level of genome products and their interactions. In this review, we will discuss the background of chiral drug investigation from which contemporary drug chirality research has emerged, the techniques involved in proteomics technology, the application of proteomics in this exciting area, and the perspectives in future applications of this field.
为了阐明手性在药物作用中的作用，人们对手性药物的手性进行了广泛研究。蛋白质组学虽然尚处于起步阶段，但最近已成为药物开发研究中的首要技术，它具有比基因组学能提供更多关于生物体有用信息的优势，因为它直接针对基因组产物及其相互作用水平。在本综述中，我们将讨论当代药物手性研究产生的手性药物研究背景、蛋白质组学技术所涉及的技术、蛋白质组学在这一令人兴奋领域的应用以及该领域未来应用的前景。
