School of Chemical and Biomedical Engineering, College of Engineering, Nanyang Technological University, Singapore.
Proteomics. 2010 Feb;10(4):888-93. doi: 10.1002/pmic.200900094.
Chiral drugs account for a large proportion of drugs available in the market. There is increasing awareness of the importance of drug chirality and the role it plays in explaining the oftentimes dramatic differences in biological activities in the current drug development portfolio. Using recently developed chiral drugs-cell interaction system, several examples of protein profiles induced by chiral drugs were illustrated in detail on the platform of 2-D LC interfaced with MS/MS system. In addition, the background of chiral drug investigation from which contemporary drug chirality research has emerged, the techniques involved in proteomics technology, the application of proteomics in this exciting area, and the perspectives in future applications are also discussed.
手性药物在市场上可用药物中占有很大比例。人们越来越意识到药物手性的重要性，以及它在手性药物开发组合中解释生物活性差异的作用。使用最近开发的手性药物-细胞相互作用系统，在手性药物诱导的蛋白质图谱平台上，详细说明了几个例子，该平台与 MS/MS 系统接口。此外，还讨论了手性药物研究的背景，蛋白质组学技术所涉及的技术，蛋白质组学在这一令人兴奋的领域中的应用以及未来应用的前景。
