绿原酸、奎尼酸和咖啡酸在体内和体外的抗乙型肝炎病毒活性
Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro.
作者信息
Wang Gui-Feng, Shi Li-Ping, Ren Yu-Dan, Liu Qun-Fang, Liu Hou-Fu, Zhang Ru-Jun, Li Zhuang, Zhu Feng-Hua, He Pei-Lan, Tang Wei, Tao Pei-Zhen, Li Chuan, Zhao Wei-Min, Zuo Jian-Ping
机构信息
Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China.
出版信息
Antiviral Res. 2009 Aug;83(2):186-90. doi: 10.1016/j.antiviral.2009.05.002. Epub 2009 May 20.
Chlorogenic acid and its related compounds are abundant plant polyphenols that have a diverse antiviral activity. In this study, HepG2.2.15 cells and duck hepatitis B virus infection model were used as in vitro and in vivo models to evaluate their anti-HBV activity. In the cell model, all the three compounds inhibited HBV-DNA replication as well as HBsAg production. Chlorogenic acid and caffeic acid also reduced serum DHBV level in DHBV-infected duckling model. Moreover, the anti-HBV activity of crude extracts of coffee beans, which have a high content of chlorogenic acid, was studied. Both the extracts of regular coffee and that of decaffeinated coffee showed inhibitory effect on HBV replication.
绿原酸及其相关化合物是丰富的植物多酚，具有多种抗病毒活性。在本研究中，HepG2.2.15细胞和鸭乙型肝炎病毒感染模型被用作体外和体内模型来评估它们的抗乙肝病毒活性。在细胞模型中，这三种化合物均抑制乙肝病毒DNA复制以及乙肝表面抗原的产生。绿原酸和咖啡酸也降低了鸭乙肝病毒感染雏鸭模型中的血清鸭乙肝病毒水平。此外，还研究了绿原酸含量高的咖啡豆粗提物的抗乙肝病毒活性。普通咖啡提取物和脱咖啡因咖啡提取物均对乙肝病毒复制有抑制作用。
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