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生物多样性到突破:沙特阿拉伯药用植物在抗病毒研究中的前景

Biodiversity to Breakthroughs: The Promise of Saudi Arabian Medicinal Plants in Antiviral Research.

作者信息

Moohammed Hamdoon A, Khan Riaz A

机构信息

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, 51452, Qassim, Saudi Arabia.

出版信息

Appl Biochem Biotechnol. 2025 Sep 10. doi: 10.1007/s12010-025-05380-4.

Abstract

Viruses are minuscule entities that cannot survive independently without a Living host. Pathogenic viruses pose a significant threat to global health, resulting annually in the deaths of thousands of people. Recent studies indicate that medicinal plants may serve as an effective source of sustainable natural antiviral agents. Saudi Arabia exhibits diverse climates, resulting in a variety of ecosystems and environmental setups with a diverse array of plant species. Diversified flora thriving in various climatic conditions produces a wide spectrum of phytochemical constituents, many of which possess antiviral and other pharmacological properties. Saudi Arabia, home to approximately 2285 distinct plant species, renders an advantageous situation for the development of novel chemopreventive and therapeutic agents for combating infectious diseases. This review seeks to secure information regarding the antiviral properties of medicinal plants and their constituent phytochemicals from Saudi Arabia. The review provides a Listing of the phytoconstituents responsible for antiviral effects, their mechanistic workings, and pathways associated with the activity. Data mined from PubMed, Scopus, ScienceDirect, Google Scholar, EMBASE, and ChemSpider are included. The findings indicate that under 5% of these plant species have been investigated for their antiviral potential, thereby highlighting a significant gap in the information source. Investigating the antiviral potential of these unexplored plant species, in all probability, may result in the identification of novel compounds for the treatment of viral infections.

摘要

病毒是极其微小的实体,没有活宿主就无法独立存活。致病性病毒对全球健康构成重大威胁,每年导致数千人死亡。最近的研究表明,药用植物可能是可持续天然抗病毒药物的有效来源。沙特阿拉伯气候多样,形成了各种生态系统和环境格局,拥有各种各样的植物物种。在各种气候条件下茁壮成长的多样化植物群产生了广泛的植物化学成分,其中许多具有抗病毒和其他药理特性。沙特阿拉伯拥有约2285种独特的植物物种,为开发新型化学预防和治疗传染病的药物提供了有利条件。本综述旨在获取有关沙特阿拉伯药用植物及其植物化学成分抗病毒特性的信息。该综述列出了具有抗病毒作用的植物成分、它们的作用机制以及与活性相关的途径。纳入了从PubMed、Scopus、ScienceDirect、谷歌学术、EMBASE和ChemSpider挖掘的数据。研究结果表明,这些植物物种中只有不到5%的抗病毒潜力得到了研究,从而凸显了信息来源方面的重大差距。研究这些未被探索的植物物种的抗病毒潜力,很可能会发现用于治疗病毒感染的新化合物。

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