Escherichia coli DegP: a structure-driven functional model.
作者信息
Ortega Joaquin, Iwanczyk Jack, Jomaa Ahmad
机构信息
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
出版信息
J Bacteriol. 2009 Aug;191(15):4705-13. doi: 10.1128/JB.00472-09. Epub 2009 May 22.
Abstract
摘要
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A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor.人HtrA2作为淀粉样β寡聚化抑制剂的新功能。
J Alzheimers Dis. 2009;17(2):281-94. doi: 10.3233/JAD-2009-1037.
2
Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control.膜上碗状寡聚结构作为DegP在蛋白质质量控制中的新功能形式。
Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4858-63. doi: 10.1073/pnas.0811780106. Epub 2009 Mar 2.
3
Characterization of the autocleavage process of the Escherichia coli HtrA protein: implications for its physiological role.大肠杆菌HtrA蛋白自切割过程的特性：对其生理作用的启示
J Bacteriol. 2009 Mar;191(6):1924-32. doi: 10.1128/JB.01187-08. Epub 2008 Dec 19.
4
The proteolytic activity of the HtrA (DegP) protein from Escherichia coli at low temperatures.大肠杆菌中HtrA（DegP）蛋白在低温下的蛋白水解活性。
Microbiology (Reading). 2008 Dec;154(Pt 12):3649-3658. doi: 10.1099/mic.0.2008/020487-0.
5
Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins.DegP伴侣蛋白酶通过与底物蛋白结合形成大型笼状寡聚体而被激活。
Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11939-44. doi: 10.1073/pnas.0805464105. Epub 2008 Aug 12.
6
Protein structure determination by x-ray crystallography.通过X射线晶体学确定蛋白质结构。
Methods Mol Biol. 2008;452:63-87. doi: 10.1007/978-1-60327-159-2_3.
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Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins.DegP的PDZ结构域与蛋白酶结构域之间的相互作用确保了错误折叠蛋白质的有效清除。
Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7702-7. doi: 10.1073/pnas.0803392105. Epub 2008 May 27.
8
Structural basis for the regulated protease and chaperone function of DegP.DegP的调控蛋白酶和伴侣功能的结构基础
Nature. 2008 Jun 12;453(7197):885-90. doi: 10.1038/nature07004. Epub 2008 May 21.
9
The mechanism of temperature-induced bacterial HtrA activation.温度诱导细菌HtrA激活的机制。
J Mol Biol. 2008 Mar 21;377(2):410-20. doi: 10.1016/j.jmb.2007.12.078. Epub 2008 Jan 11.
10
Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control.细菌蛋白质质量控制过程中应激信号对HtrA蛋白酶DegP的变构激活作用。
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