Grasping at shadows: revealing the elusive nature of essential genes.
作者信息
Msadek Tarek
机构信息
Biology of Gram-Positive Pathogens, Department of Microbiology, Institut Pasteur, Paris, France.
出版信息
J Bacteriol. 2009 Aug;191(15):4701-4. doi: 10.1128/JB.00572-09. Epub 2009 May 22.
Abstract
摘要
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From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.从群体序列到统一序列：十年后的枯草芽孢杆菌168参考基因组
Microbiology (Reading). 2009 Jun;155(Pt 6):1758-1775. doi: 10.1099/mic.0.027839-0. Epub 2009 Apr 21.
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Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12.基因组测序揭示了大肠杆菌K-12广泛使用的MC4100谱系中的调控突变和重组事件。
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Comparative genome-scale metabolic reconstruction and flux balance analysis of multiple Staphylococcus aureus genomes identify novel antimicrobial drug targets.多个金黄色葡萄球菌基因组的比较基因组规模代谢重建及通量平衡分析确定了新的抗菌药物靶点。
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New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus.对WalK/WalR（YycG/YycF）重要信号转导途径的新见解揭示了其在控制金黄色葡萄球菌细胞壁代谢和生物膜形成中的主要作用。
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