Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Eur Arch Otorhinolaryngol. 2010 Feb;267(2):303-10. doi: 10.1007/s00405-009-0996-6. Epub 2009 May 23.
This study evaluated the expression of fibronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the differences in the biological behavior of these tumors. Immunohistochemical technique was performed in 20 cases of ameloblastoma (16 solid and 4 desmoplastic) and in 10 cases of AOT. All tumors presented moderate fibronectin expression in the stroma. Solid ameloblastomas showed intense expression of fibronectin at the epithelial-mesenchymal interface, whereas desmoplastic ameloblastomas revealed no immunoexpression of fibronectin at this site. Ameloblastomas presented stronger immunoreactivity to tenascin than AOTs, especially at the epithelial-mesenchymal interface. AOTs and desmoplastic ameloblastomas showed intense labeling for type I collagen. The patterns of expression of the proteins studied agree with the locally more invasive behavior of ameloblastomas in comparison to AOTs. Our results might suggest a less invasive behavior of desmoplastic ameloblastoma in comparison to solid ameloblastoma.
本研究评估了纤维连接蛋白、腱蛋白和 I 型胶原在造釉细胞瘤和牙源性腺样瘤（AOT）中的表达，旨在帮助理解这两种肿瘤在生物学行为上的差异。对 20 例造釉细胞瘤（16 例实性和 4 例骨外生型）和 10 例 AOT 进行了免疫组织化学技术检测。所有肿瘤的基质中均表现出中度纤维连接蛋白表达。实性造釉细胞瘤在上皮-间充质界面呈现强烈的纤维连接蛋白表达，而骨外生型造釉细胞瘤在该部位无纤维连接蛋白免疫表达。造釉细胞瘤的腱蛋白免疫反应性强于 AOT，尤其是在上皮-间充质界面。AOT 和骨外生型造釉细胞瘤均表现出强烈的 I 型胶原标记。研究中蛋白质的表达模式与造釉细胞瘤在局部侵袭性方面优于 AOT 相符。我们的结果可能表明，与实性造釉细胞瘤相比，骨外生型造釉细胞瘤具有较低的侵袭性。
