DiSaia P J, Morrow C P, Haverback B J, Dyce B J
Cancer. 1977 Jun;39(6):2365-70. doi: 10.1002/1097-0142(197706)39:6<2365::aid-cncr2820390609>3.0.co;2-i.
The results of plasma carcinoembryonic antigen (CEA) determinations done over 600 patients with gynecologic malignancy will be presented. It would appear from this extensive survey that the likelihood of a patient having a positive value is increased with advancing stage and bulk of disease. The incidence of positive values in patients with clinical recurrence is quite impressive and presents a possible mode of follow-up for patients after standard treatment techniques have been administered for cervical cancer. Most interesting is the effect of radiation therapy or surgery on squamous cell cancer of the cervix and vulva in patients who have a positive value of the onset. Treatment of the disease by either modality appears to be associated with a precipitous drop in plasma value of CEA. Unfortunately, the presence or absence of CEA is not reliable and to date it is impossible to predict which patients with gynecologic malignancy will manifest a positive plasma value. Comments will be made concerning retro-de-differentiation and de-repression as a mechanism for the production of this antigen in patients with gynecologic cancer.
将展示对600多名妇科恶性肿瘤患者进行血浆癌胚抗原（CEA）测定的结果。从这项广泛的调查来看，随着疾病分期的进展和肿瘤体积的增大，患者出现阳性值的可能性会增加。临床复发患者中阳性值的发生率相当可观，这为宫颈癌患者在接受标准治疗技术后提供了一种可能的随访方式。最有趣的是，放疗或手术对发病时CEA值呈阳性的子宫颈和外阴鳞状细胞癌患者的影响。采用这两种方式中的任何一种治疗该疾病似乎都与CEA血浆值的急剧下降有关。不幸的是，CEA的存在与否并不可靠，迄今为止，还无法预测哪些妇科恶性肿瘤患者的血浆值会呈阳性。将对逆分化和去抑制作为妇科癌症患者产生这种抗原的一种机制进行讨论。
