癌胚抗原在各类肿瘤患者管理中的价值再评估。
A reappraisal of the value of carcinoembryonic antigen in the management of patients with various neoplasms.
作者信息
Cooper M J, Mackie C R, Skinner D B, Moossa A R
出版信息
Br J Surg. 1979 Feb;66(2):120-3. doi: 10.1002/bjs.1800660212.
Abstract
Eight hundred and eight patients with histologically proved malignant disease had carcinoembryonic antigen (CEA) estimations performed at the time of tissue diagnosis. An elevated level was found in 384 of 518 patients with gastrointestinal neoplasms (74 per cent) and in 162 of 290 patients with other neoplasms (56 per cent). No correlation was found between CEA elevations and tumour differentiation. There was a good correlation between tumour staging and CEA levels for patients with colorectal cancer; the more advanced the tumour, the higher the CEA. Several illustrative cases are presented and the role of CEA assay in the diagnosis and management of neoplasia is discussed. CEA assay is a poor screening test for neoplastic disease, but serial CEA monitoring is valuable in the detection of residual or recurrent cancer.
摘要
808例经组织学证实为恶性疾病的患者在组织诊断时进行了癌胚抗原（CEA）检测。在518例胃肠道肿瘤患者中，384例（74%）CEA水平升高；在290例其他肿瘤患者中，162例（56%）CEA水平升高。未发现CEA升高与肿瘤分化之间存在相关性。对于结直肠癌患者，肿瘤分期与CEA水平之间存在良好的相关性；肿瘤越晚期，CEA水平越高。文中给出了几个说明性病例，并讨论了CEA检测在肿瘤诊断和管理中的作用。CEA检测对肿瘤疾病的筛查效果不佳，但连续监测CEA对检测残留或复发性癌症很有价值。
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