Gököz Ozay, Presenti Loretta, Gambacorta Giuseppina, Zolfanelli Federica, Tricarico Rossella, Nistri Roberto, Baroni Gianna, Bianchi Simonetta, Massi Daniela
Department of Pathology, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey.
Int J Surg Pathol. 2011 Aug;19(4):527-33. doi: 10.1177/1066896909337383. Epub 2009 May 25.
Adnexal tumors with follicular differentiation in the breast parenchyma are rarely encountered. The authors present a unique case arising in a 64-year-old woman, in whom they observed composite differentiation toward follicular germinative cells of the hair follicle with focal areas of outer root sheath differentiation and pilar-type keratinization. The histogenesis of this tumor is analyzed in light of the peculiar pathological, immunohistochemical, and molecular genetic findings.
乳腺实质中具有滤泡分化的附件肿瘤很少见。作者报告了一例发生在一名64岁女性身上的独特病例，他们在该病例中观察到肿瘤向毛囊的滤泡生发细胞呈复合分化，并伴有外根鞘分化和毛干型角化的局灶性区域。根据其独特的病理、免疫组化和分子遗传学发现，对该肿瘤的组织发生进行了分析。
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