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乳腺具有皮肤附件毛干滤泡分化的侵袭性癌:一例详细免疫组化和分子分析的病例报告。

Invasive Carcinoma With Skin Adnexal Trichilemmal Hair Follicular Differentiation Occurring in the Breast: A Case Report With Detailed Immunohistochemical and Molecular Analysis.

机构信息

The University of Texas MD Anderson Cancer Center, Houston, USA.

出版信息

Int J Surg Pathol. 2024 Jun;32(4):796-802. doi: 10.1177/10668969231189166. Epub 2023 Jul 31.

Abstract

Cutaneous-type adnexal tumors involving the breast are rare and create a diagnostic dilemma as they are often indistinguishable from primary mammary neoplasms. Tumors showing hair follicular differentiation are particularly challenging due to their rarity and the subtle appreciation of the intricate microanatomy of the hair follicle. We report a triple negative cutaneous-type adnexal carcinoma with follicular differentiation involving the breast to bring attention to the existence of these specialized group of tumors which should be managed differently from conventional triple negative carcinomas of the breast.

摘要

乳腺皮肤附属器肿瘤较为罕见,给诊断带来了困难,因为它们常常与原发性乳腺肿瘤无法区分。具有毛囊分化的肿瘤由于其罕见性和对毛囊复杂微解剖结构的细微认识,具有特别大的挑战性。我们报告了一例累及乳腺的三阴性皮肤附属器癌伴毛囊分化,旨在引起对这些特殊类型肿瘤的关注,它们的处理应与常规的三阴性乳腺癌不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbbf/11099551/4c8aab3099d5/10.1177_10668969231189166-fig1.jpg

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