• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

椎间盘内注射类固醇会加速人体椎间盘的组织学退变吗？

Does intradiscal steroid injection accelerate the histological degeneration of the human disc?

作者信息

Kim Jin Hwan, Chang Sunhee, Kim Byung Ho, Lee Gyu Heon, Cho Sung Tan

机构信息

Department of Orthopaedic Surgery, Inje University Ilsan Paik Hospital, 170 Juhwa-ro, Ilsanseo-gu, Goyang-si, Gyeonggi-do, South Korea.

Department of Pathology, Inje University Ilsan Paik Hospital, 170 Juhwa-ro, Ilsanseo-gu, Goyang-si, Gyeonggi-do, South Korea.

出版信息

Osteoporos Sarcopenia. 2024 Sep;10(3):108-113. doi: 10.1016/j.afos.2024.06.001. Epub 2024 Jul 2.

DOI:10.1016/j.afos.2024.06.001
PMID:39403217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11471104/
Abstract

OBJECTIVES

Intradiscal steroid injection (ISI) use has been proven as a low-risk and rapid treatment for disc degeneration disease (DDD). However, the histological effects of steroids on human discs remain poorly understood. The purpose of this study is to investigate whether ISI induces histologic degeneration of the disc.

METHODS

In this study, a histological analysis was carried out on the nucleus pulposus obtained from 150 patients who underwent posterior lumbar interbody fusion. Among these individuals, 59 received ISI before the surgery, while 91 did not. After staining with hematoxylin and eosin, the histological classification was performed based on chondrocyte proliferation (C1, C2, and C3) and granular matrix change (M1 and M2). Logistic regression analysis was used to identify the main factors influencing chondrocyte proliferation and granular matrix change. Additionally, histological differences between the ISI group and the non-ISI group were analyzed.

RESULTS

Chondrocyte proliferation and granular matrix changes were not significantly different between the ISI and non-ISI groups. The logistic regression analysis indicated that age is the most significant risk factor for both chondrocyte proliferation (P = 0.02) and granular matrix changes (P < 0.01).

CONCLUSIONS

The most crucial factor in disc degeneration is age. ISI does not accelerate the histological degeneration of chondrocyte proliferation and granular matrix. Therefore, the ISI could be considered as a histologically safe alternative in patients with DDD.

摘要

目的

椎间盘内类固醇注射（ISI）已被证明是治疗椎间盘退变疾病（DDD）的一种低风险且快速的方法。然而，类固醇对人体椎间盘的组织学影响仍知之甚少。本研究的目的是调查ISI是否会导致椎间盘的组织学退变。

方法

在本研究中，对150例行后路腰椎椎间融合术患者所获取的髓核进行了组织学分析。在这些个体中，59例在手术前接受了ISI，而91例未接受。在用苏木精和伊红染色后，基于软骨细胞增殖（C1、C2和C3）和颗粒状基质变化（M1和M2）进行组织学分类。采用逻辑回归分析来确定影响软骨细胞增殖和颗粒状基质变化的主要因素。此外，还分析了ISI组和非ISI组之间的组织学差异。

结果

ISI组和非ISI组之间软骨细胞增殖和颗粒状基质变化无显著差异。逻辑回归分析表明，年龄是软骨细胞增殖（P = 0.02）和颗粒状基质变化（P < 0.01）的最显著风险因素。

结论

椎间盘退变的最关键因素是年龄。ISI不会加速软骨细胞增殖和颗粒状基质的组织学退变。因此，对于DDD患者，ISI可被视为一种组织学上安全的替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5788/11471104/0554c79a71b1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5788/11471104/17dfd7a16ed7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5788/11471104/063d9fd81498/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5788/11471104/a731301ad286/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5788/11471104/0554c79a71b1/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5788/11471104/17dfd7a16ed7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5788/11471104/063d9fd81498/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5788/11471104/a731301ad286/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5788/11471104/0554c79a71b1/gr4.jpg

相似文献

1
Does intradiscal steroid injection accelerate the histological degeneration of the human disc?椎间盘内注射类固醇会加速人体椎间盘的组织学退变吗？
Osteoporos Sarcopenia. 2024 Sep;10(3):108-113. doi: 10.1016/j.afos.2024.06.001. Epub 2024 Jul 2.
2
Intradiscal injection of human recombinant BMP-4 does not reverse intervertebral disc degeneration induced by nuclectomy in sheep.在绵羊中，椎间盘内注射人重组骨形态发生蛋白-4不能逆转髓核摘除术诱导的椎间盘退变。
J Orthop Translat. 2022 Sep 23;37:23-36. doi: 10.1016/j.jot.2022.08.006. eCollection 2022 Nov.
3
Intradiscal injection of monosodium iodoacetate induces intervertebral disc degeneration in an experimental rabbit model.碘酸钠单钠椎间盘内注射诱导实验性兔椎间盘退变。
Arthritis Res Ther. 2021 Dec 8;23(1):297. doi: 10.1186/s13075-021-02686-6.
4
Histologic changes in the intervertebral disc after intradiscal injections of methylprednisolone acetate in rabbits.兔椎间盘内注射醋酸甲基泼尼松龙后的组织学变化
Spine (Phila Pa 1976). 1997 Jan 15;22(2):127-31; discussion 132. doi: 10.1097/00007632-199701150-00001.
5
Regenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase.富血小板血浆洗脱液注射治疗胶原酶注射兔椎间盘退变的再生作用。
Arthritis Res Ther. 2023 Nov 8;25(1):216. doi: 10.1186/s13075-023-03200-w.
6
Pharmacological enhancement of disc diffusion and differentiation of healthy, ageing and degenerated discs : Results from in-vivo serial post-contrast MRI studies in 365 human lumbar discs.健康、衰老和退变椎间盘的盘内扩散及分化的药理学增强：365例人类腰椎间盘对比剂增强后连续体内MRI研究结果
Eur Spine J. 2008 May;17(5):626-43. doi: 10.1007/s00586-008-0645-6. Epub 2008 Mar 21.
7
The effect of spinal steroid injections for degenerative disc disease.脊柱类固醇注射治疗椎间盘退变疾病的效果。
Spine J. 2004 Sep-Oct;4(5):495-505. doi: 10.1016/j.spinee.2004.03.024.
8
Intradiscal injection of sesamin protects from lesion-induced degeneration.鞘内注射芝麻素可预防病变诱导的退化。
Connect Tissue Res. 2020 Nov;61(6):594-603. doi: 10.1080/03008207.2019.1651847. Epub 2019 Aug 20.
9
Comparison of Adjacent Segment Degeneration After Nonrigid Fixation System and Posterior Lumbar Interbody Fusion for Single-Level Lumbar Disc Herniation: A New Method of MRI Analysis of Lumbar Nucleus Pulposus Volume.非刚性固定系统与后路腰椎椎间融合术治疗单节段腰椎间盘突出症后相邻节段退变的比较：一种新的腰椎髓核体积MRI分析方法
J Invest Surg. 2018 Aug;31(4):307-312. doi: 10.1080/08941939.2017.1325542. Epub 2017 May 19.
10
1997 Volvo Award winner in basic science studies. Immunohistologic markers for age-related changes of human lumbar intervertebral discs.1997年沃尔沃基础科学研究奖获得者。人类腰椎间盘退变的免疫组织学标志物。
Spine (Phila Pa 1976). 1997 Dec 15;22(24):2781-95. doi: 10.1097/00007632-199712150-00001.

引用本文的文献

1
Effectiveness of intradiscal steroid injection for spinal stenosis: a retrospective cohort study in South Korea.椎间盘内注射类固醇治疗腰椎管狭窄症的疗效：韩国的一项回顾性队列研究。
Asian Spine J. 2025 Aug;19(4):545-552. doi: 10.31616/asj.2024.0513. Epub 2025 Apr 22.

本文引用的文献

1
The Potency of Platelet-Rich Plasma for Chronic Low Back Pain: A Systematic Review and Metaanalysis of Randomized Controlled Trial.富血小板血浆治疗慢性下腰痛的疗效：一项随机对照试验的系统评价和荟萃分析
Asian Spine J. 2023 Aug;17(4):782-789. doi: 10.31616/asj.2022.0209. Epub 2023 May 15.
2
Diagnostic Modality in Spine Disease: A Review.脊柱疾病的诊断方式：综述
Asian Spine J. 2020 Dec;14(6):910-920. doi: 10.31616/asj.2020.0593. Epub 2020 Dec 22.
3
Degeneration of Lumbar Intervertebral Discs: Characterization of Anulus Fibrosus Tissue and Cells of Different Degeneration Grades.
腰椎间盘退变：不同退变程度的纤维环组织和细胞特征。
Int J Mol Sci. 2020 Mar 21;21(6):2165. doi: 10.3390/ijms21062165.
4
Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease.椎间盘疾病 PART 2：椎间盘疾病当前诊断与治疗策略综述。
Int J Mol Sci. 2020 Mar 20;21(6):2135. doi: 10.3390/ijms21062135.
5
Safety of intradiscal delivery of triamcinolone acetonide by a poly(esteramide) microsphere platform in a large animal model of intervertebral disc degeneration.在椎间盘退变的大动物模型中，聚（酯酰胺）微球平台经皮向椎间盘内注射曲安奈德的安全性。
Spine J. 2019 May;19(5):905-919. doi: 10.1016/j.spinee.2018.10.014. Epub 2018 Oct 26.
6
Musculoskeletal Corticosteroid Administration: Current Concepts.肌肉骨骼系统皮质类固醇给药：当前概念。
Can Assoc Radiol J. 2019 Feb;70(1):29-36. doi: 10.1016/j.carj.2018.11.002.
7
Clinical Pharmacology of Corticosteroids.皮质类固醇的临床药理学
Respir Care. 2018 Jun;63(6):655-670. doi: 10.4187/respcare.06314.
8
Lumbar disc degeneration is associated with modic change and high paraspinal fat content - a 3.0T magnetic resonance imaging study.腰椎间盘退变与Modic改变及椎旁高脂肪含量相关——一项3.0T磁共振成像研究
BMC Musculoskelet Disord. 2016 Oct 21;17(1):439. doi: 10.1186/s12891-016-1297-z.
9
Mechanics and biology in intervertebral disc degeneration: a vicious circle.椎间盘退变的力学与生物学：恶性循环。
Osteoarthritis Cartilage. 2015 Jul;23(7):1057-70. doi: 10.1016/j.joca.2015.03.028. Epub 2015 Mar 27.
10
A validated new histological classification for intervertebral disc degeneration.一种经过验证的新的椎间盘退变组织学分类。
Osteoarthritis Cartilage. 2013 Dec;21(12):2039-47. doi: 10.1016/j.joca.2013.10.001. Epub 2013 Oct 10.