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椎间盘内注射类固醇治疗腰椎管狭窄症的疗效:韩国的一项回顾性队列研究。

Effectiveness of intradiscal steroid injection for spinal stenosis: a retrospective cohort study in South Korea.

作者信息

Kim Jin Hwan, Cho Sung Tan, Kim Byung Jik, Chae Su Whi, Liawrungrueang Wongthawat

机构信息

Department of Orthopaedic Surgery, Ilsan Paik Hospital, Inje University, Goyang, Korea.

Department of Orthopaedic Surgery, Seoul Seonam Hospital, Seoul, Korea.

出版信息

Asian Spine J. 2025 Aug;19(4):545-552. doi: 10.31616/asj.2024.0513. Epub 2025 Apr 22.

DOI:10.31616/asj.2024.0513
PMID:40259644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12400097/
Abstract

STUDY DESIGN

A retrospective cohort study.

PURPOSE

This study aimed to evaluate the efficacy of intradiscal steroid injection (ISI) in managing patients with spinal stenosis.

OVERVIEW OF LITERATURE

ISI has shown effectiveness in relieving lower back pain in patients with degenerative disc disease. However, its potential utility in managing the symptoms of spinal stenosis remains unexplored.

METHODS

This study included 260 patients with spinal stenosis who complained of lower back pain and radiating pain in the lower extremities. During the ISI, a mixture of 1 mL of dexamethasone 5 mg and 1 mL of ropivacaine 0.2% was administered. Pain levels were assessed at weeks 2 and 6 after ISI using the Visual Analog Scale (VAS) for back and leg pain. Patients requiring surgery within a year because of persistent or worsening symptoms were analyzed, and pain score changes between the surgical and nonsurgical groups were compared.

RESULTS

ISI significantly reduced the initial back pain VAS score (8.85) and leg pain VAS score (8.91) at weeks 2 (back pain=4.58; p<0.001, leg pain=4.42; p<0.001) and 6 (back pain=4.79; p<0.001, leg pain=4.70; p<0.001). A total of 228 patients (87.7%) showed improvement of initial symptoms without the need for surgery 1 year after ISI. The surgical and nonsurgical groups showed improvement in leg and back pain VAS scores 2 weeks after ISI. However, in the surgical group, a significant trend was noted toward worsening back and leg pain VAS score at week 6 after ISI.

CONCLUSIONS

ISI effectively provided temporary pain relief for patients with lumbar spinal stenosis. The majority of patients, up to 1 year later, only necessitate conservative management of their symptoms and do not require surgery. In particular, if the improvement in pain persists up to 6 weeks after the ISI, surgical intervention may be delayed in favor of more conservative treatments.

摘要

研究设计

一项回顾性队列研究。

目的

本研究旨在评估椎间盘内注射类固醇(ISI)治疗腰椎管狭窄症患者的疗效。

文献综述

ISI已显示出对退行性椎间盘疾病患者缓解下背痛有效。然而,其在控制腰椎管狭窄症症状方面的潜在效用仍未得到探索。

方法

本研究纳入了260例主诉下背痛和下肢放射性疼痛的腰椎管狭窄症患者。在ISI过程中,给予1 mL含5 mg地塞米松和1 mL 0.2%罗哌卡因的混合液。在ISI后第2周和第6周,使用视觉模拟量表(VAS)评估背部和腿部疼痛的疼痛程度。对因症状持续或恶化而在一年内需要手术的患者进行分析,并比较手术组和非手术组之间的疼痛评分变化。

结果

ISI在第2周(背痛=4.58;p<0.001,腿痛=4.42;p<0.001)和第6周(背痛=4.79;p<0.001,腿痛=4.70;p<0.001)时显著降低了初始背痛VAS评分(8.85)和腿痛VAS评分(8.91)。共有228例患者(87.7%)在ISI后1年时无需手术即显示初始症状改善。手术组和非手术组在ISI后2周时腿部和背部疼痛VAS评分均有所改善。然而,在手术组中,ISI后第6周时背部和腿部疼痛VAS评分有显著恶化趋势。

结论

ISI有效地为腰椎管狭窄症患者提供了临时疼痛缓解。大多数患者,直至1年后,仅需要对其症状进行保守治疗,无需手术。特别是,如果ISI后疼痛改善持续至6周,则可推迟手术干预,优先采用更保守的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d48/12400097/b47f49212025/asj-2024-0513f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d48/12400097/2658b643cc40/asj-2024-0513f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d48/12400097/1bdbb9ffedab/asj-2024-0513f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d48/12400097/b47f49212025/asj-2024-0513f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d48/12400097/2658b643cc40/asj-2024-0513f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d48/12400097/1bdbb9ffedab/asj-2024-0513f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d48/12400097/b47f49212025/asj-2024-0513f3.jpg

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