Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100730, People's Republic of China.
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, People's Republic of China.
J Ovarian Res. 2018 Apr 19;11(1):30. doi: 10.1186/s13048-018-0405-0.
Synchronous endometrial disorders have been poorly studied in women with endometrioid borderline ovarian tumors (EBOT). The aims of this study were to investigate the risk of endometrial disorders among women with EBOT and associated factors, as well as their oncological and fertility outcomes.
This retrospective study included 33 women with EBOT. Their mean age was 41.9 years, and endometria were evaluated in 25 of these patients. The prevalence of synchronous endometrial disorders was 52.0% (n = 13/25) and this incidence was 41.4% (n = 46/111) after systematic analysis. Univariable analysis showed that EBOT patients who were younger, nulliparous, and had experienced abnormal vaginal bleeding were more likely to have synchronous endometrial disorders. The median follow-up was 54 months (range: 14-250 months), and three patients (10.3%) developed recurrences. No deaths due to EBOT were recorded. Among the nine nulliparous women treated conservatively who were attempting to conceive, only one (11.1%) pregnancy resulted in a live birth.
Synchronous endometrial disorders are common in women with EBOT, especially in those who are younger, nulliparous, and have experienced abnormal vaginal bleeding. Thus, endometrial sampling should be performed in women with EBOT undergoing conservative surgery, and a hysterectomy should be performed in cases requiring radical treatment.
子宫内膜同步病变在子宫内膜样交界性卵巢肿瘤（EBOT）患者中研究甚少。本研究旨在探讨 EBOT 患者发生子宫内膜病变的风险及相关因素，以及她们的肿瘤学和生育结局。
本回顾性研究纳入 33 例 EBOT 患者。她们的平均年龄为 41.9 岁，其中 25 例患者的子宫内膜得到了评估。同步子宫内膜病变的患病率为 52.0%（n=13/25），在系统分析后这一发病率为 41.4%（n=46/111）。单变量分析显示，年轻、未产和经历异常阴道出血的 EBOT 患者更有可能发生同步子宫内膜病变。中位随访时间为 54 个月（范围：14-250 个月），有 3 例（10.3%）患者复发。未记录到 EBOT 死亡病例。在 9 例接受保守治疗并试图怀孕的未产妇女中，仅有 1 例（11.1%）妊娠导致活产。
EBOT 患者中同步子宫内膜病变很常见，尤其是年轻、未产和经历异常阴道出血的患者。因此，对于行保守手术的 EBOT 患者应进行子宫内膜取样，对于需要根治性治疗的患者应行子宫切除术。
