Tyner Elaine, McClean Brendan, McCavana Patrick, af Wetterstedt Sacha
St. Luke's Hospital, Highfield Road, Rathgar Dublin 6, Ireland.
Med Phys. 2009 Apr;36(4):1318-29. doi: 10.1118/1.3089424.
The characteristics of an Elekta amorphous silicon (a-Si) electronic portal imaging device (EPID) in response to a 6 MV photon beam generated without a flattening filter, an unflattened beam, have been determined. The characteristics were then compared to those for a conventional photon beam generated with a flattening filter in the beam, a flattened beam, in order to determine the suitability of an a-Si EPID for transit dosimetry. The response of the EPID to the unflattened beam increased by 7.3% compared to the flattened beam, and copper buildup of 3 mm reduces the variation in the EPID response over air gaps ranging from 60 to 40 cm to within 2.5%. The scattering properties of the EPID with changing field size for the unflattened beam agree with those measured for a flattened beam to within 2%. Due to the minimal variation in the energy spectrum of the unflattened beam with the distance from the central axis, it was expected and experimentally found that the profile shape of the unflattened beam changes minimally with increasing phantom thickness. For an unflattened beam, EPID measured profiles with and without a phantom in the beam agree to within 2% using confidence limits. The difference between EPID and ionization chamber profiles measured at a depth of 5 cm in water is reduced compared to a flattened beam and remains unchanged with increasing phantom thickness. A difference of 4% was found between EPID profiles and the corresponding profiles measured with an ionization chamber measured in water over a range of phantom thickness. A calibration procedure was developed to convert EPID images to the equivalent absolute dose in water, at the EPID plane. A gamma evaluation was performed comparing the calibrated EPID images to dose measured with an ionization chamber array for rectangular fields and an IMRT segment. The fields were situated on axis and at 5 cm off axis with and without a 25 cm thick phantom in the beam. The gamma evaluation criteria of 3% and 3 mm were met within the field, for all fields examined. This study concludes that a-Si EPIDs are suitable dosimeters for IMRT treatments using unflattened photon beams with the advantage that the characteristics of the unflattened beam result in a reduction in the number of measurements necessary to calibrate an a-Si EPID as a transit dosimeter.
已确定医科达非晶硅(a-Si)电子射野影像装置(EPID)对未加均整滤过器产生的6兆伏光子束(即非均整束)的响应特性。然后将这些特性与在束中使用均整滤过器产生的传统光子束(即均整束)的特性进行比较,以确定a-Si EPID用于传输剂量测定的适用性。与均整束相比,EPID对非均整束的响应增加了7.3%,3毫米的铜等效物可将EPID响应在60至40厘米气隙范围内的变化减小到2.5%以内。对于非均整束,随着射野大小变化,EPID的散射特性与均整束测量值的吻合度在2%以内。由于非均整束的能谱随离中心轴距离的变化极小,预计并通过实验发现,非均整束的剖面形状随模体厚度增加变化极小。对于非均整束,在束中有模体和无模体时,EPID测量的剖面在置信限内的吻合度在2%以内。与均整束相比,在水中5厘米深度处测量时,EPID与电离室剖面之间的差异减小,且随模体厚度增加保持不变。在一系列模体厚度范围内,发现EPID剖面与在水中用电离室测量的相应剖面之间存在4%的差异。已制定校准程序,将EPID图像转换为EPID平面处水中的等效绝对剂量。针对矩形野和调强放疗(IMRT)射野,对校准后的EPID图像与用电离室阵列测量的剂量进行了伽马评估。射野位于中心轴上以及离轴5厘米处,束中有和没有25厘米厚的模体。对于所有检查的射野,在射野内均满足3%和3毫米的伽马评估标准。本研究得出结论,a-Si EPID是适用于使用非均整光子束进行IMRT治疗的剂量计,其优势在于非均整束的特性减少了将a-Si EPID校准为传输剂量计时所需的测量次数。