病毒对DNA修复和细胞周期检查点的操控。
Viral manipulation of DNA repair and cell cycle checkpoints.
作者信息
Chaurushiya Mira S, Weitzman Matthew D
机构信息
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
出版信息
DNA Repair (Amst). 2009 Sep 2;8(9):1166-76. doi: 10.1016/j.dnarep.2009.04.016. Epub 2009 May 26.
Recognition and repair of DNA damage is critical for maintaining genomic integrity and suppressing tumorigenesis. In eukaryotic cells, the sensing and repair of DNA damage are coordinated with cell cycle progression and checkpoints, in order to prevent the propagation of damaged DNA. The carefully maintained cellular response to DNA damage is challenged by viruses, which produce a large amount of exogenous DNA during infection. Viruses also express proteins that perturb cellular DNA repair and cell cycle pathways, promoting tumorigenesis in their quest for cellular domination. This review presents an overview of strategies employed by viruses to manipulate DNA damage responses and cell cycle checkpoints as they commandeer the cell to maximize their own viral replication. Studies of viruses have identified key cellular regulators and revealed insights into molecular mechanisms governing DNA repair, cell cycle checkpoints, and transformation.
DNA损伤的识别与修复对于维持基因组完整性和抑制肿瘤发生至关重要。在真核细胞中，DNA损伤的感知与修复与细胞周期进程及检查点相协调，以防止受损DNA的传播。精心维持的细胞对DNA损伤的反应受到病毒的挑战，病毒在感染过程中会产生大量外源DNA。病毒还表达干扰细胞DNA修复和细胞周期途径的蛋白质，在其寻求细胞主导地位的过程中促进肿瘤发生。本综述概述了病毒在 commandeer 细胞以最大化自身病毒复制时，用于操纵DNA损伤反应和细胞周期检查点的策略。对病毒的研究已确定关键的细胞调节因子，并揭示了控制DNA修复、细胞周期检查点和转化的分子机制。 （注：“commandeer”此处可能有误，未准确理解其在文中的含义，按原文翻译）
Zotero 插件