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[艾滋病患者的食管念珠菌病。19例临床、内镜及组织病理学分析]

[Esophageal candidiasis in AIDS. Clinical, endoscopic, and histopathologic analysis of 19 cases].

作者信息

Rodríguez Hernández H, Reyes Gutiérrez E, Elizondo Rivera J

机构信息

Departamento de Endoscopía, Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F.

出版信息

Rev Invest Clin. 1991 Apr-Jun;43(2):124-7.

PMID:1947465
Abstract

From May 1988 to December 1989, fiberoptic endoscopy of the upper digestive tract was performed in 53 patients with AIDS. In 19 cases a presumptive diagnosis of candida esophagitis was made: 13 were men and six women; the median age was 38.9 years. The Kodsi grading scale was used to evaluate the extent of the fungal colonization. In five patients no symptoms were found, eight did not show oral candidiasis; dysphagia in seven cases and odynophagia in five cases were the main esophageal complaints. Eleven cases showed pan-esophagitis, but three cases showed only the distal portion involvement. Grade II lesions were observed in ten patients, and four had grades I or III. No correlation was found between the symptoms and the grade score. Direct brushing cytology of the esophageal lesions corroborated the endoscopic diagnosis. Association with other opportunistic infections were detected only in one case. Our findings corroborates the usefulness of the fiberoptic esophageal endoscopy to improve the diagnosis of AIDS-related esophageal candidiasis in patients without symptoms or oral lesions.

摘要

1988年5月至1989年12月,对53例艾滋病患者进行了上消化道纤维内镜检查。19例患者被初步诊断为念珠菌食管炎:13例男性,6例女性;中位年龄为38.9岁。采用科兹分级量表评估真菌定植程度。5例患者无症状,8例未出现口腔念珠菌病;7例吞咽困难和5例吞咽痛是主要的食管症状。11例表现为全食管炎,但3例仅累及远端部分。10例患者观察到II级病变,4例为I级或III级。症状与分级评分之间未发现相关性。食管病变的直接刷检细胞学检查证实了内镜诊断。仅在1例中检测到与其他机会性感染相关。我们的研究结果证实了纤维食管内镜检查对改善无症状或无口腔病变患者艾滋病相关食管念珠菌病诊断的有用性。

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