人体视网膜和视神经的体内高分辨率视频速率光谱域光学相干断层扫描

In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve.

作者信息

Nassif N, Cense B, Park B, Pierce M, Yun S, Bouma B, Tearney G, Chen T, de Boer J

出版信息

Opt Express. 2004 Feb 9;12(3):367-76. doi: 10.1364/opex.12.000367.

DOI:10.1364/opex.12.000367

PMID:19474832

Abstract

An ultra-high-speed spectral-domain optical coherence tomography system (SD-OCT) was developed for imaging the human retina and optic nerve in vivo at a sustained depth profile (A-line) acquisition speed of 29 kHz. The axial resolution was 6 microm in tissue and the system had shot-noise-limited performance with a maximum sensitivity of 98.4 dB. 3-dimensional data sets were collected in 11 and 13 seconds for the macula and optic nerve head respectively and are presented to demonstrate the potential clinical applications of SD-OCT in ophthalmology. Additionally, a 3-D volume of the optic nerve head was constructed from the acquired data and the retinal vascular network was visualized.

摘要

开发了一种超高速光谱域光学相干断层扫描系统（SD-OCT），用于以29 kHz的持续深度剖面（A线）采集速度对人体视网膜和视神经进行体内成像。该系统在组织中的轴向分辨率为6微米，具有散粒噪声限制性能，最大灵敏度为98.4 dB。分别在11秒和13秒内收集了黄斑和视神经头的三维数据集，以展示SD-OCT在眼科的潜在临床应用。此外，从采集的数据构建了视神经头的三维体积，并对视网膜血管网络进行了可视化。