Sterenborg H, de Wolf J, Koning M, Kruijt B, van den Heuvel A, Robinson D
Opt Express. 2004 May 3;12(9):1873-8. doi: 10.1364/opex.12.001873.
The effectiveness of photodynamic therapy is strongly dependent on the availabilty of oxygen. In the present paper we show that the ratio between photosensitiser phosphorescence and fluorescence is a parameter that can be used to monitor the competition between singlet oxygen production and other processes quenching the photosensitiser triplet state. We present a theoretical basis for the validity of this approach and a series of in vitro imaging experiments.
光动力疗法的有效性很大程度上取决于氧气的可利用性。在本文中，我们表明光敏剂磷光与荧光的比率是一个可用于监测单线态氧产生与淬灭光敏剂三重态的其他过程之间竞争的参数。我们为该方法的有效性提供了理论基础，并进行了一系列体外成像实验。
