Broeders Mariëlle E A C, Sanchis Joaquin, Levy Mark L, Crompton Graham K, Dekhuijzen P N Richard
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Prim Care Respir J. 2009 Jun;18(2):76-82. doi: 10.4104/pcrj.2009.00025.
Aerosol inhalation is considered the optimal route for administering the majority of drugs for the treatment of obstructive airways diseases. A number of Pressurised Metered-Dose and Dry Powder Inhalers are available for this purpose. However, inhalation of therapeutic aerosols is not without difficulty; it requires precise instructions on the inhalation manoeuvre, which is different from spontaneous normal breathing. Also, the characteristics of the inhaler device have to be suitable for the user. Available data indicate a frequent lack of knowledge demonstrated by health professionals and patients on the inhalation manoeuvre and handling of inhalers, resulting in a reduction of therapeutic benefit. This paper reviews the literature concerning the fundamental aspects of inhaler devices, inhalation manoeuvre and device selection, in an attempt to increase the knowledge of, and to optimise the clinical use of, therapeutic inhalers.
对于大多数用于治疗阻塞性气道疾病的药物而言，气溶胶吸入被认为是最佳给药途径。为此有多种压力定量吸入器和干粉吸入器可供使用。然而，吸入治疗性气溶胶并非毫无困难；它需要关于吸入动作的精确指导，而这与自然的正常呼吸不同。此外，吸入器装置的特性必须适合使用者。现有数据表明，医护人员和患者在吸入动作及吸入器使用方面常常缺乏相关知识，从而导致治疗效果降低。本文回顾了有关吸入器装置、吸入动作和装置选择等基本方面的文献，旨在增加对治疗性吸入器的了解并优化其临床应用。
