Park Sun-Young, Choi Jinhee
Faculty of Environmental Engineering, College of Urban Science, University of Seoul, 90 Jeonnong-dong, Dongdaemun-gu, Seoul 130-743, Korea.
Bull Environ Contam Toxicol. 2009 Oct;83(4):463-8. doi: 10.1007/s00128-009-9745-1. Epub 2009 May 28.
The geno-, and eco-toxicity of nonlyphenol (NP) and bisphenol A (BPA) were investigated in Daphnia magna, and Chironomus riparius. BPA may exert a genotoxicity on both species, whereas NP-induced DNA damage occurred only in C. riparius. In NP-exposed D. magna, increased mortality, without effect on DNA integrity was observed, an example of a false-negative result from the biomarkers perspective. False-positive results from the genotoxicity were observed in BPA-exposed D. magna and in NP-exposed C. riparius. Considering the importance of genotoxic biomarkers in ecotoxicity monitoring, DNA damage in these species could provide useful information.
研究了壬基酚(NP)和双酚A(BPA)对大型溞和摇蚊的基因毒性和生态毒性。BPA可能对这两个物种都产生基因毒性,而NP诱导的DNA损伤仅发生在摇蚊中。在暴露于NP的大型溞中,观察到死亡率增加,但对DNA完整性没有影响,从生物标志物的角度来看,这是一个假阴性结果的例子。在暴露于BPA的大型溞和暴露于NP的摇蚊中观察到了基因毒性的假阳性结果。考虑到基因毒性生物标志物在生态毒性监测中的重要性,这些物种中的DNA损伤可以提供有用的信息。