垂序商陆提取物对去卵巢大鼠骨质疏松症的改善作用。

Ameliorative effects of Vaccaria segetalis extract on osteopenia in ovariectomized rats.

机构信息

Institute of Pharmaceutical Science and Technology, College of Health Science, Central Taiwan University of Science and Technology, 11, Po-Tze Lane, Takun, Taichung, Taiwan, ROC.

出版信息

J Nat Med. 2009 Oct;63(4):386-92. doi: 10.1007/s11418-009-0341-9. Epub 2009 May 28.

DOI:10.1007/s11418-009-0341-9

PMID:19475478

Abstract

The purpose of this study was to determine the ameliorative effects of a crude extract of Vaccaria segetalis (Neck.) Garcke (Caryophyllaceae) (VSE) on osteopenia in ovariectomized (OVX) rats over 12 weeks. Rats were divided into the sham and OVX groups. The OVX rats were allowed to lose bone for 6 weeks. At 6 weeks post-OVX, the OVX rats were divided into four groups treated with water, 17beta-estradiol (30 microg/kg, daily subcutaneous injection), or VSE (0.5 or 1.0 g/kg, daily, orally) for 6 weeks. In OVX rats, the increases of serum total cholesterol were significantly decreased by VSE or 17beta-estradiol treatment. There were decreases in bone density and calcium content, including the left femur and the fourth lumbar vertebra, when compared with the sham control rats. Treatment with 17beta-estradiol or VSE ameliorated these changes induced by OVX. In addition, ovariectomy increased urinary deoxypyridinoline (DPD) amounts (P < 0.001). The increases were suppressed by 17beta-estradiol and 0.5 or 1.0 g/kg VSE (P < 0.01, P < 0.05, P < 0.01, respectively). Our results demonstrated that VSE ameliorates ovariectomy-induced osteopenia by inhibition of bone resorption.

摘要

本研究旨在确定垂序商陆（苋科）粗提物（VSE）对去卵巢（OVX）大鼠骨质疏松症的改善作用，为期 12 周。大鼠分为假手术组和 OVX 组。OVX 大鼠允许骨质丢失 6 周。OVX 后 6 周，将 OVX 大鼠分为四组，分别给予水、17β-雌二醇（30μg/kg，每日皮下注射）或 VSE（0.5 或 1.0g/kg，每日口服）治疗 6 周。在 OVX 大鼠中，VSE 或 17β-雌二醇治疗可显著降低血清总胆固醇的升高。与假手术对照组相比，骨密度和钙含量（包括左股骨和第四腰椎）降低。17β-雌二醇或 VSE 治疗可改善 OVX 引起的这些变化。此外，卵巢切除术后尿脱氧吡啶啉（DPD）量增加（P<0.001）。17β-雌二醇和 0.5 或 1.0g/kg VSE 抑制了这些增加（P<0.01，P<0.05，P<0.01，分别）。我们的结果表明，VSE 通过抑制骨吸收来改善卵巢切除术后引起的骨质疏松症。