Tian Meng, Huang Yuwen, Wang Xin, Cao Maosheng, Zhao Zijiao, Chen Tong, Yuan Chenfeng, Wang Nan, Zhang Boqi, Li Chunjin, Zhou Xu
College of Animal Sciences, Jilin University, Changchun, China.
Front Chem. 2021 Apr 29;9:666280. doi: 10.3389/fchem.2021.666280. eCollection 2021.
is a dry mature seed of Vaccaria hispanica (Mill.) Rauschert, which belongs to the genus (Neck.) Garcke. There are multiple medicinal parts of , according to the records, including roots, stems, leaves, flowers, and seeds, which should be used together. Currently, is most frequently used in the treatment of menstruation, dysmenorrhea, breast milk stoppages, and chylorrhea. Numerous studies present historical evidence of the use of to treat several diseases and describe its beneficial effects including prolactin- (PRL-) like, estrogen-like, antitumor, antiangiogenesis, and antioxidant activity. We summarized the period from January 1980 to December 2019 regarding . This review paper indicates that has promising clinical applications. The main active ingredients of the plant have been elucidated in recent years. We summarized the previously and newly discovered pharmacological effects of in addition to its active ingredients, ethnopharmacological uses, and toxicological properties, and provided a focus for future research.
王不留行是麦蓝菜（Vaccaria hispanica (Mill.) Rauschert）干燥的成熟种子，麦蓝菜属于石竹科（Caryophyllaceae）麦蓝菜属（Vaccaria (Neck.) Garcke）。据记载，王不留行有多个药用部位，包括根、茎、叶、花和种子，应一起使用。目前，王不留行最常用于治疗月经不调、痛经、乳汁不通和乳糜尿。众多研究提供了使用王不留行治疗多种疾病的历史证据，并描述了其有益作用，包括催乳素（PRL）样、雌激素样、抗肿瘤、抗血管生成和抗氧化活性。我们总结了1980年1月至2019年12月期间关于王不留行的研究。这篇综述文章表明王不留行具有广阔的临床应用前景。近年来，该植物的主要活性成分已得到阐明。我们总结了王不留行先前和新发现的药理作用、活性成分、民族药理学用途和毒理学特性，并为未来的研究提供了重点。
