Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Jie Fang Road, Hangzhou, Zhejiang, People's Republic of China.
Int Urol Nephrol. 2010 Mar;42(1):95-102. doi: 10.1007/s11255-009-9584-3. Epub 2009 May 28.
MicroRNAs (miRNAs) have recently been shown to down-regulate gene expression by targeting mRNA translation and to play a critical role in tumorigenesis; how they regulate bladder tumor development, particularly in patients, is, however, poorly understood. The difference in miRNA expression in a bladder tumor compared with healthy tissue from the same patients was examined using microRNA arrays in seven patients. Here, we showed that up-regulation of miRNA was not commonly found in this limited number of patients, and four miRNAs (miR-26a, miR-29c, miR-30c, miR-30e-5p) were down-regulated as a common marker in patients with a 1-3 grade of disease. Our data suggest that instead of up-regulation of carcinogenic miRNAs, loss of regulation of these miRNA may be critical for bladder tumor development in patients.
MicroRNAs (miRNAs) 最近被证明可以通过靶向 mRNA 翻译来下调基因表达，并在肿瘤发生中发挥关键作用；然而，它们如何调节膀胱癌的发生，特别是在患者中，仍知之甚少。我们使用 miRNA 芯片在 7 名患者中检查了膀胱癌组织和同一患者的健康组织之间的 miRNA 表达差异。在这里，我们表明，在这有限数量的患者中，miRNA 的上调并不常见，并且有 4 种 miRNA（miR-26a、miR-29c、miR-30c、miR-30e-5p）作为疾病 1-3 级患者的共同标志物下调。我们的数据表明，对于患者膀胱癌的发生，这些 miRNA 的调控丢失可能比致癌 miRNA 的上调更为关键。
