Jiang Zhong-Xing, Liu Xin, Jeong Eun-Kee, Yu Yihua Bruce
Fischell Department of Bioengineering, University of Maryland, College Park, USA.
Angew Chem Int Ed Engl. 2009;48(26):4755-8. doi: 10.1002/anie.200901005.
Getting FIT: A bispherical (19)F imaging tracer, (19)FIT, was designed and synthesized. (19)FIT is advantageous over perfluorocarbon-based (19)F imaging agents, as it is not retained in the organs and does not require complex formulation procedures. Imaging agents such as (19)FIT can lead to (19)F magnetic resonance imaging (MRI) playing an important role in drug therapy, analogous to the role played by (1)H MRI in disease diagnosis.
获得FIT：设计并合成了一种双球形（19）F成像示踪剂（19）FIT。（19）FIT比基于全氟碳的（19）F成像剂更具优势，因为它不会在器官中滞留，也不需要复杂的配制程序。像（19）FIT这样的成像剂可使（19）F磁共振成像（MRI）在药物治疗中发挥重要作用，类似于（1）H MRI在疾病诊断中所起的作用。
