用于（19）F磁共振成像的稳定且快速排泄的成像示踪剂的对称引导设计与氟相合成
Symmetry-guided design and fluorous synthesis of a stable and rapidly excreted imaging tracer for (19)F MRI.
作者信息
Jiang Zhong-Xing, Liu Xin, Jeong Eun-Kee, Yu Yihua Bruce
机构信息
Fischell Department of Bioengineering, University of Maryland, College Park, USA.
出版信息
Angew Chem Int Ed Engl. 2009;48(26):4755-8. doi: 10.1002/anie.200901005.
Abstract
Getting FIT: A bispherical (19)F imaging tracer, (19)FIT, was designed and synthesized. (19)FIT is advantageous over perfluorocarbon-based (19)F imaging agents, as it is not retained in the organs and does not require complex formulation procedures. Imaging agents such as (19)FIT can lead to (19)F magnetic resonance imaging (MRI) playing an important role in drug therapy, analogous to the role played by (1)H MRI in disease diagnosis.
摘要
获得FIT：设计并合成了一种双球形（19）F成像示踪剂（19）FIT。（19）FIT比基于全氟碳的（19）F成像剂更具优势，因为它不会在器官中滞留，也不需要复杂的配制程序。像（19）FIT这样的成像剂可使（19）F磁共振成像（MRI）在药物治疗中发挥重要作用，类似于（1）H MRI在疾病诊断中所起的作用。
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