Lu Chun-Hua, Yang Huang-Hao, Zhu Chun-Ling, Chen Xi, Chen Guo-Nan
The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China.
Angew Chem Int Ed Engl. 2009;48(26):4785-7. doi: 10.1002/anie.200901479.
Sensitive platform: The use of graphene oxide (GO) as a platform for the sensitive and selective detection of DNA and proteins is presented. The interaction of GO and dye-labeled single-stranded DNA leads to quenching of the dye fluorescence. Conversely, the presence of a target DNA or protein leads to the binding of the dye-labeled DNA and target, releasing the DNA from GO, thereby restoring the dye fluorescence (see picture).
介绍了使用氧化石墨烯（GO）作为灵敏且选择性检测DNA和蛋白质的平台。GO与染料标记的单链DNA相互作用会导致染料荧光猝灭。相反，目标DNA或蛋白质的存在会导致染料标记的DNA与目标结合，使DNA从GO上释放，从而恢复染料荧光（见图）。
