有机汞寡核苷酸-聚多巴胺纳米颗粒组装体通过汞（II）介导的碱基配对区分靶序列。
Organomercury oligonucleotide-polydopamine nanoparticle assemblies discriminate between target sequences by Hg(ii)-mediated base pairing.
作者信息
Kotammagari Tharun K, Al-Waeel Majid, Lukkari Jukka, Lönnberg Tuomas
机构信息
Department of Chemistry, University of Turku Henrikinkatu 2 20500 Turku Finland
出版信息
RSC Adv. 2024 Dec 3;14(51):38279-38284. doi: 10.1039/d4ra07922a. eCollection 2024 Nov 25.
Abstract
A fluorescently tagged oligonucleotide hybridization probe incorporating a single 5-mercuricytosine residue was synthesized and found to adsorb on polydopamine nanoparticles much more strongly than its unmetallated counterpart. Hybridization with target sequences led to release of the probe from the nanoparticle to varying degrees depending on the nucleobase opposite to 5-mercuricytosine.
摘要
合成了一种包含单个5-汞代胞嘧啶残基的荧光标记寡核苷酸杂交探针，发现它比未金属化的对应物更强烈地吸附在聚多巴胺纳米颗粒上。与靶序列杂交会导致探针从纳米颗粒上不同程度地释放，这取决于与5-汞代胞嘧啶相对的核碱基。
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