Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh City, India.
Phytother Res. 2010 Jan;24(1):107-12. doi: 10.1002/ptr.2879.
There is documented evidence of the use of Terminalia chebula for various ailments in the Ayurvedic literature. The extract has been shown to possess glucose lowering activity and to improve insulin sensitivity in animal models of type 2 diabetes mellitus. The present study was carried out to study the dose response relationship of this extract in a rat model of metabolic syndrome. Six groups of rats were fed a high fructose diet (HFD) for a period of 20 days to induce metabolic syndrome. Three doses of fruit extract of T. chebula 50, 100 and 200 mg/kg were administered orally and pioglitazone 2.7 mg/kg was used as a positive control. Blood samples were collected at days 0, 20 and 40 from the tail vein. Systolic blood pressure (SBP) was measured using the tail cuff method and an oral glucose tolerance test (OGTT) was done on the day of blood collection. Administration of HFD for 20 days significantly increased fasting blood glucose (FBG), SBP and the area under the curve of OGTT. On day 40 the FBG in the 50, 100 and 200 mg/kg group was 97.33 +/- 5.82 (NS), 86.83 +/- 5.08 (p = 0.038) and 85.67 +/- 6.74 (p = 0.15), respectively. These results show that the fruit extract of T. chebula exerts a significant and dose-dependent glucose lowering effect in the rat model of metabolic syndrome.
有文献证明，诃子在印度草医学文献中被用于多种疾病。该提取物已被证明具有降低血糖的活性，并能改善 2 型糖尿病动物模型的胰岛素敏感性。本研究旨在研究这种提取物在代谢综合征大鼠模型中的剂量反应关系。六组大鼠喂食高果糖饮食（HFD）20 天，以诱导代谢综合征。给予三种剂量的诃子果实提取物 50、100 和 200mg/kg 口服，吡格列酮 2.7mg/kg 作为阳性对照。从尾静脉采集 0、20 和 40 天的血样。使用尾套法测量收缩压（SBP），并在采血当天进行口服葡萄糖耐量试验（OGTT）。喂食 HFD 20 天显著增加空腹血糖（FBG）、SBP 和 OGTT 的曲线下面积。第 40 天，50、100 和 200mg/kg 组的 FBG 分别为 97.33 +/- 5.82（无显著性差异）、86.83 +/- 5.08（p = 0.038）和 85.67 +/- 6.74（p = 0.15）。这些结果表明，诃子果实提取物在代谢综合征大鼠模型中具有显著的、剂量依赖性的降血糖作用。
