来自椭圆叶金丝桃的新型二苯甲酮 O-葡萄糖苷。

New benzophenone O-glucoside from Hypericum ellipticum.

作者信息

Petrunak Elyse, Kester Andrew C, Liu Yunbao, Bowen-Forbes Camile S, Nair Muraleedharan G, Henry Geneive E

机构信息

Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, PA 17870, USA.

出版信息

Nat Prod Commun. 2009 Apr;4(4):507-10.

PMID:19475994

Abstract

Examination of the acetone extract of the aerial parts of Hypericum ellipticum afforded a new acetylated benzophenone glucoside (3'-O-beta-D-3",4",6"-triacetylglucopyranosyl-2,4,5',6-tetrahydroxybenzophenone) together with catechin and epicatechin. The structure of the benzophenone glucoside was determined by 2D NMR spectroscopic data. The compound inhibited the proliferation of CNS tumor cell line (SF-268) and lipid peroxidation in in vitro assays.

摘要

对椭圆叶金丝桃地上部分的丙酮提取物进行研究，得到了一种新的乙酰化二苯甲酮葡萄糖苷（3'-O-β-D-3",4",6"-三乙酰吡喃葡萄糖基-2,4,5',6-四羟基二苯甲酮）以及儿茶素和表儿茶素。通过二维核磁共振光谱数据确定了二苯甲酮葡萄糖苷的结构。该化合物在体外试验中抑制中枢神经系统肿瘤细胞系（SF-268）的增殖和脂质过氧化。