Drennan M D, Kripke D F, Klemfuss H A, Moore J D
Department of Psychiatry, University of California-San Diego.
Sleep. 1991 Aug;14(4):357-60.
The present study examines the effects of potassium supplementation on sleep quality and phase, as indirectly inferred from wrist actigraphy and sleep logs, in normal young males on a low-potassium diet. A randomized, double-blind, placebo-controlled, counterbalanced crossover design compared 1 wk of oral potassium chloride supplements (96 meq/day) to 1 wk of identical placebo capsules. Outcome measures were taken from sleep logs and wrist actigraphy. Sleep was indirectly inferred from wrist-actigraph data using a computer algorithm. Potassium supplementation significantly delayed sleep-log-identified Bedtime (p less than 0.001). Potassium reduced Sleeping Interval for both sleep-log (p less than 0.01) and wrist-actigraph (p less than 0.1) data. Potassium significantly increased actigraphic Sleep Efficiency (p less than 0.05) due to a reduction in actigraphic Wake after Sleep Onset (WASO) (p less than 0.05). No effect of potassium on actigraphic sleep phase was observed. Side effects were minimal and not significantly different between treatment conditions. The results may indicate an improvement in sleep consolidation with potassium supplementation. Further studies using standard polysomnography are required to define potassium's effects on human sleep.
本研究通过腕动图和睡眠日志间接推断，探讨了低钾饮食的正常年轻男性补充钾对睡眠质量和睡眠阶段的影响。采用随机、双盲、安慰剂对照、平衡交叉设计，将1周的口服氯化钾补充剂（96毫当量/天）与1周的相同安慰剂胶囊进行比较。结果指标来自睡眠日志和腕动图。使用计算机算法从腕动图数据间接推断睡眠情况。补充钾显著延迟了睡眠日志确定的就寝时间（p<0.001）。对于睡眠日志（p<0.01）和腕动图（p<0.1）数据，钾均缩短了睡眠时间间隔。由于睡眠开始后腕动图记录的觉醒时间（WASO）减少（p<0.05），钾显著提高了腕动图记录的睡眠效率（p<0.05）。未观察到钾对腕动图睡眠阶段有影响。副作用极小，且不同治疗条件之间无显著差异。结果可能表明补充钾可改善睡眠巩固。需要进一步使用标准多导睡眠图进行研究，以确定钾对人类睡眠的影响。
